Antidepressants increase human hippocampal neurogenesis by activating the glucocorticoid receptor

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Pariante , Carmine; Anacker , Christoph; Zunszain , Patricia A; Cattaneo , Annamaria; Carvalho , Livia A; Thuret , Sandrine; Price , Jack; Garabedian , Michael J;
  • Publisher: Nature Publishing Group
  • Journal: MOLECULAR PSYCHIATRY,volume 16,issue 7,pages738-750 (issn: 1359-4184, eissn: 1476-5578)
  • Related identifiers: pmc: PMC3121947, doi: 10.1038/mp.2011.26
  • Subject: Molecular Biology | stem cells | Original Article | /dk/atira/pure/subjectarea/asjc/2700/2738 | Cellular and Molecular Neuroscience | adult hippocampal neurogenesis | /dk/atira/pure/subjectarea/asjc/2800/2804 | /dk/atira/pure/subjectarea/asjc/1300/1312 | depression | glucocorticoids | neuroplasticity | Psychiatry and Mental health

International audience; Antidepressants increase adult hippocampal neurogenesis in animal models, but the underlying molecular mechanisms are unknown. Here we used human hippocampal progenitor cells to investigate the molecular pathways involved in the antidepressant-in... View more
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