Burning Cold: Involvement of TRPA1 in Noxious Cold Sensation

Article English OPEN
Kwan, Kelvin Y; Corey, David Paul;
  • Publisher: The Rockefeller University Press
  • Journal: volume 133,issue 3,pages251-256issn: 0022-1295, eissn: 1540-7748
  • Related identifiers: pmc: PMC2654090, doi: 10.1085/jgp.200810146
  • Subject: Perspective
    mesheuropmc: food and beverages | psychological phenomena and processes

Soon after its discovery ten years ago, the ion channel TRPA1 was proposed as a sensor of noxious cold. Evidence for its activation by painfully cold temperatures (below ~15° C) has been mixed, however. Some groups found that cold elicits a nonselective conductance in c... View more
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