Alpha 1 Antitrypsin Inhibits Dendritic Cell Activation and Attenuates Nephritis in a Mouse Model of Lupus

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Elshikha, Ahmed S.; Lu, Yuanqing; Chen, Mong-Jen; Akbar, Mohammad; Zeumer, Leilani; Ritter, Andrea; Elghamry, Hanaa; Mahdi, Mahmoud A.; Morel, Laurence; Song, Sihong;
(2016)
  • Publisher: Public Library of Science
  • Journal: PLoS ONE,volume 11,issue 5 (issn: 1932-6203, eissn: 1932-6203)
  • Related identifiers: doi: 10.1371/journal.pone.0156583, pmc: PMC4883758
  • Subject: Mouse Models | Immune System Proteins | Animal Models | Cell Differentiation | Research Article | Diagnostic Medicine | Lupus Erythematosus | Signs and Symptoms | Proteinuria | Rheumatology | Pathology and Laboratory Medicine | Immunoassays | Clinical Medicine | Systemic Lupus Erythematosus | Molecular Development | Proteins | Immune System | Enzyme-Linked Immunoassays | Cytokines | Antibodies | Immunology | Autoantibodies | Autoimmune Diseases | Biology and Life Sciences | Immune Physiology | Developmental Biology | Research and Analysis Methods | Physiology | Medicine | Immunologic Techniques | Innate Immune System | Q | R | Secretion | Model Organisms | Clinical Immunology | Science | Biochemistry | Medicine and Health Sciences | Physiological Processes
    mesheuropmc: skin and connective tissue diseases | immune system diseases

Systemic lupus erythematosus (SLE) is an autoimmune disorder with a worldwide distribution and considerable mortality and morbidity. Although the pathogenesis of this disease remains elusive, over-reactive dendritic cells (DCs) play a critical role in the disease develo... View more
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