Characterization of Dopaminergic System in the Striatum of Young Adult Park2−/− Knockout Rats

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Gemechu, Jickssa M.; Sharma, Akhil; Yu, Dongyue; Xie, Yuran; Merkel, Olivia M.; Moszczynska, Anna;

Abstract Mutations in parkin gene (Park2) are linked to early-onset autosomal recessive Parkinson’s disease (PD) and young-onset sporadic PD. Park2 knockout (PKO) rodents; however, do not display neurodegeneration of the nigrostriatal pathway, suggesting age-dependent c... View more
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