Epicutaneous Immunization with Type II Collagen Inhibits both Onset and Progression of Chronic Collagen-Induced Arthritis

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Strid, J; Tan, LA; Strobel, S; Londei, M; Callard, R;
(2007)
  • Publisher: Public Library of Science
  • Journal: PLoS ONE,volume 2,issue 4 (issn: 1932-6203, eissn: 1932-6203)
  • Related identifiers: doi: 10.1371/journal.pone.0000387, pmc: PMC1849892
  • Subject: Research Article | Arthritis, Experimental | Collagen Type II | Animals, Antibodies, Arthritis, Experimental, Cell Proliferation, Collagen Type II, Disease Progression, Interferon-gamma, Mice, Mice, Inbred DBA, Skin, T-Lymphocytes | Rheumatology/Autoimmunity, Autoimmune, and Inflammatory Diseases | Skin | Disease Progression | Mice | Immunology/Autoimmunity | Mice, Inbred DBA | Antibodies | Animals | Interferon-gamma | MD Multidisciplinary | Cell Proliferation | Medicine | Dermatology/Skin and Systemic Disease | Rheumatology/Rheumatoid Arthritis | Immunology/Immunomodulation | Q | R | T-Lymphocytes | Science | General Science & Technology
    mesheuropmc: chemical and pharmacologic phenomena

Epicutaneous immunization is a potential non-invasive technique for antigen-specific immune-modulation. Topical application of protein antigens to barrier-disrupted skin induces potent antigen-specific immunity with a strong Th2-bias. In this study, we investigate wheth... View more
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