Epicutaneous Immunization with Type II Collagen Inhibits both Onset and Progression of Chronic Collagen-Induced Arthritis

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Strid, J; Tan, LA; Strobel, S; Londei, M; Callard, R;
  • Publisher: Public Library of Science
  • Journal: PLoS ONE,volume 2,issue 4 (issn: 1932-6203, eissn: 1932-6203)
  • Related identifiers: doi: 10.1371/journal.pone.0000387, pmc: PMC1849892
  • Subject: Research Article | Arthritis, Experimental | Collagen Type II | Animals, Antibodies, Arthritis, Experimental, Cell Proliferation, Collagen Type II, Disease Progression, Interferon-gamma, Mice, Mice, Inbred DBA, Skin, T-Lymphocytes | Rheumatology/Autoimmunity, Autoimmune, and Inflammatory Diseases | Skin | Disease Progression | Mice | Immunology/Autoimmunity | Mice, Inbred DBA | Antibodies | Animals | Interferon-gamma | MD Multidisciplinary | Cell Proliferation | Medicine | Dermatology/Skin and Systemic Disease | Rheumatology/Rheumatoid Arthritis | Immunology/Immunomodulation | Q | R | T-Lymphocytes | Science | General Science & Technology
    mesheuropmc: chemical and pharmacologic phenomena

Epicutaneous immunization is a potential non-invasive technique for antigen-specific immune-modulation. Topical application of protein antigens to barrier-disrupted skin induces potent antigen-specific immunity with a strong Th2-bias. In this study, we investigate wheth... View more
  • References (39)
    39 references, page 1 of 4

    1. Strid J, Hourihane J, Kimber I, Callard R, Strobel S (2204) Disruption of the stratum corneum allows potent epicutaneous immunization with protein antigens resulting in a dominant systemic Th2 response. Eur J Immunol 34: 2100-2109.

    2. Wang LF, Lin JY, Hsieh KH, Lin RH (1996) Epicutaneous exposure of protein antigen induces a predominant Th2-like response with high IgE production in mice. J Immunol 156: 4077-4082.

    3. Herrick CA, Xu L, McKenzie AN, Tigelaar RE, Bottomly K (2003) IL-13 is necessary, not simply sufficient, for epicutaneously induced Th2 responses to soluble protein antigen. J Immunol 170: 2488-2495.

    4. Glenn GM, Taylor DN, Li X, Frankel S, Montemarano A, et al. (2000) Transcutaneous immunization: a human vaccine delivery strategy using a patch. Nat Med 6: 1403-1406.

    5. Partidos CD, Beignon AS, Briand JP, Muller S (2004) Modulation of immune responses with transcutaneously deliverable adjuvants. Vaccine 22: 2385-2390.

    6. Strid J, Callard R, Strobel S (2006) Epicutaneous immunization converts subsequent and established antigen-specific Th1- to Th2-type responses. Immunology 119: 27-35.

    7. Kondo H, Ichikawa Y, Imokawa G (1998) Percutaneous sensitization with allergens through barrier-disrupted skin elicits a Th2-dominant cytokine response. Eur J Immunol 28: 769-779.

    8. Feldmann M (2001) Pathogenesis of arthritis: recent research progress. Nat Immunol 2: 771-773.

    9. Feldmann M, Brennan FM, Maini RN (1996) Rheumatoid arthritis. Cell 85: 307-310.

    10. Miossec P, van den Berg W (1997) Th1/Th2 cytokine balance in arthritis. Arthritis Rheum 40: 2105-2115.

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