Cholesterol-Dependent Energy Transfer between Fluorescent Proteins—Insights into Protein Proximity of APP and BACE1 in Different Membranes in Niemann-Pick Type C Disease Cells

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Bjoern von Einem; Petra Weber; Michael Wagner; Martina Malnar; Marko Kosicek; Silva Hecimovic; Christine A. F. von Arnim; Herbert Schneckenburger;
  • Publisher: Molecular Diversity Preservation International (MDPI)
  • Journal: International Journal of Molecular Sciences,volume 13,issue 12,pages15,801-15,812 (issn: 1422-0067, eissn: 1422-0067)
  • Publisher copyright policies & self-archiving
  • Related identifiers: pmc: PMC3546662, doi: 10.3390/ijms131215801
  • Subject: APP | NPC | Chemistry | BACE1 | generalized polarization | QD1-999 | neurodegeneration | FRET | Article | QH301-705.5 | TIRFM | laurdan | cholesterol | Biology (General)
    mesheuropmc: mental disorders

Förster resonance energy transfer (FRET) -based techniques have recently been applied to study the interactions between β-site APP-cleaving enzyme-GFP (BACE1-GFP) and amyloid precursor protein-mRFP (APP-mRFP) in U373 glioblastoma cells. In this context... View more
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