AM-37 and ST-36 Are Small Molecule Bombesin Receptor Antagonists

Article English OPEN
Moody, Terry W. ; Tashakkori, Nicole ; Mantey, Samuel A. ; Moreno, Paola ; Ramos-Alvarez, Irene ; Leopoldo, Marcello ; Jensen, Robert T. (2017)
  • Publisher: Frontiers Media S.A.
  • Journal: Frontiers in Endocrinology, volume 8 (issn: 1664-2392, eissn: 1664-2392)
  • Related identifiers: doi: 10.3389/fendo.2017.00176, doi: 10.3389/fendo.2017.00176/full, pmc: PMC5519534
  • Subject: small molecule antagonists | lung cancer | bombesin receptor subtype-3 | RC648-665 | Diseases of the endocrine glands. Clinical endocrinology | Original Research | NMBR | GRPR | Endocrinology

While peptide antagonists for the gastrin-releasing peptide receptor (BB2R), neuromedin B receptor (BB1R), and bombesin (BB) receptor subtype-3 (BRS-3) exist, there is a need to develop non-peptide small molecule inhibitors for all three BBR. The BB agonist (BA)1 binds ... View more
Share - Bookmark