A General Linear Relaxometry Model of R1 Using Imaging Data

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Callaghan, M.; Helms, G.; Lutti, A.; Mohammad, S.; Weiskopf, N.;
  • Publisher: BlackWell Publishing Ltd
  • Journal: Magnetic Resonance in Medicine,volume 73,issue 3,pages1,309-1,314 (issn: 0740-3194, eissn: 1522-2594)
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  • Related identifiers: pmc: PMC4359013, doi: 10.1002/mrm.25210
  • Subject: 3T | relaxometry | MT | 3T, MT, PD, PD*, R1, R2*, T1, T2*, longitudinal relaxation, magnetization transfer, quantitative, relaxometry, transverse relaxation, water content | R2* | longitudinal relaxation | T2* | Computer Processing and Modeling—Note | transverse relaxation | PD | quantitative | PD* | water content | magnetization transfer | T1 | R1

PURPOSE: The longitudinal relaxation rate (R1 ) measured in vivo depends on the local microstructural properties of the tissue, such as macromolecular, iron, and water content. Here, we use whole brain multiparametric in vivo data and a general linear relaxometry model ... View more
  • References (30)
    30 references, page 1 of 3

    1. Fatouros PP, Marmarou A. Use of magnetic resonance imaging for in vivo measurements of water content in human brain: method and normal values. J Neurosurg 1999;90:109-115.

    2. Fatouros PP, Marmarou A, Kraft KA, Inao S, Schwarz FP. In vivo brain water determination by T1 measurements: effect of total water content, hydration fraction, and field strength. Magn Reson Med 1991;17:402-413.

    3. Kaneoke Y, Furuse M, Inao S, Saso K, Yoshida K, Motegi Y, Mizuno M, Izawa A. Spin-lattice relaxation times of bound water-its determination and implications for tissue discrimination. Magn Reson Imaging 1987;5:415-420.

    4. Shuter B, Wang SC, Roche J, Briggs G, Pope JM. Relaxivity of GdEOB-DTPA in the normal and biliary obstructed guinea pig. J Magn Reson Imaging 1998;8:853-861.

    5. Donahue KM, Burstein D, Manning WJ, Gray ML. Studies of GdDTPA relaxivity and proton exchange rates in tissue. Magn Reson Med 1994;32:66-76.

    6. Kamman RL, Go KG, Brouwer W, Berendsen HJ. Nuclear magnetic resonance relaxation in experimental brain edema: effects of water concentration, protein concentration, and temperature. Magn Reson Med 1988;6:265-274.

    7. Fullerton GD, Potter JL, Dornbluth NC. NMR relaxation of protons in tissues and other macromolecular water solutions. Magn Reson Imaging 1982;1:209-226.

    8. Gelman N, Ewing JR, Gorell JM, Spickler EM, Solomon EG. Interregional variation of longitudinal relaxation rates in human brain at 3.0 T: relation to estimated iron and water contents. Magn Reson Med 2001;45:71-79.

    9. Wolff SD, Balaban RS. Magnetization transfer contrast (MTC) and tissue water proton relaxation in vivo. Magn Reson Med 1989;10: 135-144.

    10. Helms G, Dathe H, Kallenberg K, Dechent P. High-resolution maps of magnetization transfer with inherent correction for RF inhomogeneity and T1 relaxation obtained from 3D FLASH MRI. Magn Reson Med 2008;60:1396-1407.

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