Connexin hemichannel blockade is neuroprotective after asphyxia in preterm fetal sheep.

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Davidson, Joanne O.; Drury, Paul P.; Green, Colin R.; Nicholson, Louise F.; Bennet, Laura; Gunn, Alistair J.;
  • Publisher: Public Library of Science (PLoS)
  • Journal: PLoS ONE, volume 9, issue 5 (issn: 1932-6203, eissn: 1932-6203)
  • Publisher copyright policies & self-archiving
  • Related identifiers: doi: 10.1371/journal.pone.0096558, pmc: PMC4035262
  • Subject: Systems Biology | Research Article | Biology and Life Sciences | Anatomy | Cell Physiology | Physiology | Medicine | Q | R | Nervous System | Cell Biology | Science | Cerebral Palsy | Nervous System Physiology | Medicine and Health Sciences | Integrative Physiology | Neurology

Asphyxia around the time of preterm birth is associated with neurodevelopmental disability. In this study, we tested the hypothesis that blockade of connexin hemichannels would improve recovery of brain activity and reduce cell loss after asphyxia in preterm fetal sheep... View more
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