Topical methotrexate pretreatment enhances the therapeutic effect of topical 5-aminolevulinic acid-mediated photodynamic therapy on hamster buccal pouch precancers

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Deng-Fu Yang; Jeng-Woei Lee; Hsin-Ming Chen; Yih-Chih Hsu;
  • Publisher: Elsevier BV
  • Journal: Journal of the Formosan Medical Association, volume 113, issue 9, pages 591-599 (issn: 0929-6646)
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  • Identifiers: doi: 10.1016/j.jfma.2014.03.002
  • Subject: oral precancerous lesions | R5-920 | hamster buccal pouch precancer | Medicine (General) | methotrexate | Medicine(all) | topical photodynamic therapy | 5-aminolevulinic acid

Topical 5-aminolevulinic acid-mediated photodynamic therapy (ALA-PDT) is effective for treatment of human oral precancerous lesions. This animal study aimed to assess whether topical methotrexate (MTX) pretreatment could enhance the therapeutic effect of topical ALA-PDT... View more
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