Identifying amyloid pathology–related cerebrospinal fluid biomarkers for Alzheimer's disease in a multicohort study

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Leung, Yuk Yee; Toledo, Jon B.; Nefedov, Alexey; Polikar, Robi; Raghavan, Nandini; Xie, Sharon X.; Farnum, Michael; Schultz, Tim; Baek, Young; Van Deerlin, Vivianna M.; Hu, William T.; Holtzman, David M.; Fagan, Anne M.; Perrin, Richard J.; Grossman, Murray; Soares, Holly D.; Kling, Mitchel A.; Mailman, Matthew; Arnold, Steven E.; Narayan, Vaibhav A.; Lee, Virginia M-Y.; Shaw, Leslie M.; Baker, David; Wittenberg, Gayle M.; Trojanowski, John Q.; Wang, Li-San;

Introduction The dynamic range of cerebrospinal fluid (CSF) amyloid β (Aβ1–42) measurement does not parallel to cognitive changes in Alzheimer's disease (AD) and cognitively normal (CN) subjects across different studies. Therefore, identifying novel proteins to characte... View more