Pharmacokinetics of Py-Im Polyamides Depend on Architecture: Cyclic versus Linear

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Raskatov, Jevgenij A.; Hargrove, Amanda E.; So, Alex Y.; Dervan, Peter B.;

The pharmacokinetic properties of three pyrrole-imidazole (Py-Im) polyamides of similar size and Py-Im content but different shape were studied in the mouse. Remarkably, hairpin and cyclic oligomers programmed for the same DNA sequence 5′-WGGWWW-3′ displayed distinct ph... View more
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