The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized

Article, Other literature type English OPEN
van Delft, Mark F. ; Wei, Andrew H. ; Mason, Kylie D. ; Vandenberg, Cassandra J. ; Chen, Lin ; Czabotar, Peter E. ; Willis, Simon N. ; Scott, Clare L. ; Day, Catherine L. ; Cory, Suzanne ; Adams, Jerry M. ; Roberts, Andrew W. ; Huang, David C.S. (2006)
  • Publisher: Elsevier BV
  • Journal: Cancer Cell, volume 10, issue 5, pages 389-399 (issn: 1535-6108)
  • Related identifiers: pmc: PMC2953559, doi: 10.1016/j.ccr.2006.08.027
  • Subject: Cell Biology | Cancer Research | Oncology | Article

Since apoptosis is impaired in malignant cells overexpressing pro-survival Bcl-2 proteins, drugs mimicking their natural antagonists, BH3-only proteins, might overcome chemoresistance. Of seven putative BH3 mimetics tested, only ABT-737 triggered Bax/Bak-mediated apopto... View more
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