Characterization of cyclic peptides containing disulfide bonds

Article, Other literature type English OPEN
Johnson, Mindy ; Liu, Mingtao ; Struble, Elaine ; Hettiarachchi, Kanthi (2015)
  • Publisher: Elsevier BV
  • Journal: Journal of Pharmaceutical and Biomedical Analysis, volume 109, pages 112-120 (issn: 0731-7085)
  • Related identifiers: pmc: PMC4608431, doi: 10.1016/j.jpba.2015.01.009
  • Subject: Drug Discovery | Spectroscopy | Pharmaceutical Science | Clinical Biochemistry | Analytical Chemistry | Article

Unlike linear peptides, analysis of cyclic peptides containing disulfide bonds is not straightforward and demands indirect methods to achieve a rigorous proof of structure. Three peptides that belong to this category, p-Cl-Phe-DPDPE, DPDPE, and CTOP, were analyzed and t... View more
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