Genome-Wide Gene-Environment Study Identifies Glutamate Receptor Gene GRIN2A as a Parkinson's Disease Modifier Gene via Interaction with Coffee

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Hamza, Taye H. ; Chen, Honglei ; Hill-Burns, Erin M. ; Rhodes, Shannon L. ; Montimurro, Jennifer ; Kay, Denise M. ; Tenesa, Albert ; Kusel, Victoria I. ; Sheehan, Patricia ; Eaaswarkhanth, Muthukrishnan ; Yearout, Dora ; Samii, Ali ; Roberts, John W. ; Agarwal, Pinky ; Bordelon, Yvette ; Park, Yikyung ; Wang, Liyong ; Gao, Jianjun ; Vance, Jeffery M. ; Kendler, Kenneth S. ; Bacanu, Silviu-Alin ; Scott, William K. ; Ritz, Beate ; Nutt, John ; Factor, Stewart A. ; Zabetian, Cyrus P. ; Payami, Haydeh (2011)
  • Publisher: Public Library of Science
  • Journal: volume 7, issue 8 (issn: 1553-7390, eissn: 1553-7404)
  • Related identifiers: doi: 10.1371/journal.pgen.1002237, pmc: PMC3158052
  • Subject: Molecular Biology | Research Article | /dk/atira/pure/subjectarea/asjc/1100/1105 | Gene-Environment Interaction | Cancer Research | QH426-470 | Genetics | /dk/atira/pure/subjectarea/asjc/1300/1311 | Polymorphism, Single Nucleotide | /dk/atira/pure/subjectarea/asjc/1300/1312 | Female | Case-Control Studies | Genome, Human | Risk Factors | Genetics(clinical) | Biology | Medicine | Ecology, Evolution, Behavior and Systematics | Parkinson Disease | Genotype | /dk/atira/pure/subjectarea/asjc/2700/2716 | Coffee | Genome-Wide Association Study | /dk/atira/pure/subjectarea/asjc/1300/1306 | Genetic Predisposition to Disease | Humans | Receptors, N-Methyl-D-Aspartate | Male

Our aim was to identify genes that influence the inverse association of coffee with the risk of developing Parkinson's disease (PD). We used genome-wide genotype data and lifetime caffeinated-coffee-consumption data on 1,458 persons with PD and 931 without PD from the N... View more
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