Genome-wide gene-environment study identifies glutamate receptor gene GRIN2A as a Parkinson's disease modifier gene via interaction with coffee.

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Taye H Hamza; Honglei Chen; Erin M Hill-Burns; Shannon L Rhodes; Jennifer Montimurro; Denise M Kay; Albert Tenesa; Victoria I Kusel; Patricia Sheehan; Muthukrishnan Eaaswarkhanth; Dora Yearout; Ali Samii; John W Roberts; Pinky Agarwal; Yvette Bordelon; Yikyung Park; Liyong Wang; Jianjun Gao; Jeffery M Vance; Kenneth S Kendler; Silviu-Alin Bacanu; William K Scott; Beate Ritz; John Nutt; Stewart A Factor; Cyrus P Zabetian; Haydeh Payami;
  • Publisher: Public Library of Science (PLoS)
  • Journal: PLoS Genetics,volume 7,issue 8 (issn: 1553-7404, eissn: 1553-7404)
  • Related identifiers: doi: 10.1371/journal.pgen.1002237, pmc: PMC3158052
  • Subject: Molecular Biology | Research Article | /dk/atira/pure/subjectarea/asjc/1100/1105 | Gene-Environment Interaction | Cancer Research | QH426-470 | Genetics | /dk/atira/pure/subjectarea/asjc/1300/1311 | Polymorphism, Single Nucleotide | /dk/atira/pure/subjectarea/asjc/1300/1312 | Female | Case-Control Studies | Genome, Human | Risk Factors | Genetics(clinical) | Biology | Medicine | Ecology, Evolution, Behavior and Systematics | Parkinson Disease | Genotype | /dk/atira/pure/subjectarea/asjc/2700/2716 | Coffee | Genome-Wide Association Study | /dk/atira/pure/subjectarea/asjc/1300/1306 | Genetic Predisposition to Disease | Humans | Receptors, N-Methyl-D-Aspartate | Male

Our aim was to identify genes that influence the inverse association of coffee with the risk of developing Parkinson's disease (PD). We used genome-wide genotype data and lifetime caffeinated-coffee-consumption data on 1,458 persons with PD and 931 without PD from the N... View more