X-linked G6PD deficiency protects hemizygous males but not heterozygous females against severe malaria.

Article English OPEN
Aldiouma Guindo; Rick M Fairhurst; Ogobara K Doumbo; Thomas E Wellems; Dapa A Diallo;
  • Publisher: Public Library of Science (PLoS)
  • Journal: PLoS Medicine,volume 4,issue 3 (issn: 1549-1277, eissn: 1549-1676)
  • Publisher copyright policies & self-archiving
  • Related identifiers: pmc: PMC1820604, doi: 10.1371/journal.pmed.0040066
  • Subject: Research Article | Infectious Diseases | Microbiology | Medicine | Malaria | Epidemiology | Hematology | R | Evolutionary Biology | Genetics | Public Health and Epidemiology | Hematology (including Blood Transfusion)
    mesheuropmc: hemic and lymphatic diseases | parasitic diseases

Editors' Summary Background. “Favism” is a condition that results from a deficiency in an enzyme called glucose-6-phosphate dehydrogenase (G6PD), and this disorder is thought to be the commonest enzyme-deficiency disease worldwide. The disease is named favism after the ... View more
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