publication . Article . Other literature type . 2015

Tumour exosome integrins determine organotropic metastasis

Name: Tumour exosome integrins determine organotropic metastasis
Keywords: Liver, Lung, Brain, Cell Line, Tumor, Fibroblasts, Kupffer Cells, Endothelial Cells, Epithelial Cells, Animals, Mice, Inbred C57BL, Humans, Neoplasm Metastasis, S100 Proteins, Integrin alpha6beta1, Integrins, Integrin beta Chains, Integrin beta4, Integrin alpha6beta4, Receptors, Vitronectin, Organ Specificity, Tropism, Phosphorylation, Genes, src, Female, Exosomes, Biomarkers, Liver Disease, Cancer, Digestive Diseases, 2.1 Biological and endogenous factors, General Science & Technology, Article

Tari A. King; Angela Di Giannatale; Maneesh Jain; Bruno Costa-Silva; Paul M. Grandgenett; Ayuko Hoshino; Leonard H. Wexler; Lindsay A. Pharmer; Kunihiro Uryu; Mina J. Bissell; ...

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Open Access

Published: 28 Oct 2015

Publisher: eScholarship, University of California

Country: United States

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Abstract

© 2015 Macmillan Publishers Limited. All rights reserved. Ever since Stephen Paget's 1889 hypothesis, metastatic organotropism has remained one of cancer's greatest mysteries. Here we demonstrate that exosomes from mouse and human lung-, liver- and brain-tropic tumour cells fuse preferentially with resident cells at their predicted destination, namely lung fibroblasts and epithelial cells, liver Kupffer cells and brain endothelial cells. We show that tumour-derived exosomes uptaken by organ-specific cells prepare the pre-metastatic niche. Treatment with exosomes from lung-tropic models redirected the metastasis of bone-tropic tumour cells. Exosome proteomics rev...

doi: 10.1038/nature15756

pmc: PMC4788391

pmid: 26524530

Subjects

free text keywords: Liver, Lung, Brain, Cell Line, Tumor, Fibroblasts, Kupffer Cells, Endothelial Cells, Epithelial Cells, Animals, Mice, Inbred C57BL, Humans, Neoplasm Metastasis, S100 Proteins, Integrin alpha6beta1, Integrins, Integrin beta Chains, Integrin beta4, Integrin alpha6beta4, Receptors, Vitronectin, Organ Specificity, Tropism, Phosphorylation, Genes, src, Female, Exosomes, Biomarkers, Liver Disease, Cancer, Digestive Diseases, 2.1 Biological and endogenous factors, General Science & Technology, Article, Microvesicles, Exosome, medicine.disease, medicine, Liver cytology, Cell culture, Integrin, biology.protein, biology, Immunology, Cancer research, Metastasis

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NIH| Characterization and Functional Analysis of Breast Cancer Secreted Exosomes in Ma, NIH| MOUSE GENETICS, NIH| Exosome-mediated Transfer of c-MET to Bone Marrow Progenitors Promotes Metastasis

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Summary