publication . Article . Other literature type . 2015

Tumour exosome integrins determine organotropic metastasis

Tari A. King; Angela Di Giannatale; Maneesh Jain; Bruno Costa-Silva; Paul M. Grandgenett; Ayuko Hoshino; Leonard H. Wexler; Lindsay A. Pharmer; Kunihiro Uryu; Mina J. Bissell; ...
Open Access
  • Published: 28 Oct 2015
  • Publisher: eScholarship, University of California
  • Country: United States
Abstract
© 2015 Macmillan Publishers Limited. All rights reserved. Ever since Stephen Paget's 1889 hypothesis, metastatic organotropism has remained one of cancer's greatest mysteries. Here we demonstrate that exosomes from mouse and human lung-, liver- and brain-tropic tumour cells fuse preferentially with resident cells at their predicted destination, namely lung fibroblasts and epithelial cells, liver Kupffer cells and brain endothelial cells. We show that tumour-derived exosomes uptaken by organ-specific cells prepare the pre-metastatic niche. Treatment with exosomes from lung-tropic models redirected the metastasis of bone-tropic tumour cells. Exosome proteomics rev...
Subjects
free text keywords: Liver, Lung, Brain, Cell Line, Tumor, Fibroblasts, Kupffer Cells, Endothelial Cells, Epithelial Cells, Animals, Mice, Inbred C57BL, Humans, Neoplasm Metastasis, S100 Proteins, Integrin alpha6beta1, Integrins, Integrin beta Chains, Integrin beta4, Integrin alpha6beta4, Receptors, Vitronectin, Organ Specificity, Tropism, Phosphorylation, Genes, src, Female, Exosomes, Biomarkers, Liver Disease, Cancer, Digestive Diseases, 2.1 Biological and endogenous factors, General Science & Technology, Article, Microvesicles, Exosome, medicine.disease, medicine, Liver cytology, Cell culture, Integrin, biology.protein, biology, Immunology, Cancer research, Metastasis
Funded by
NIH| Characterization and Functional Analysis of Breast Cancer Secreted Exosomes in Ma
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 1U01CA169538-01
  • Funding stream: NATIONAL CANCER INSTITUTE
,
NIH| MOUSE GENETICS
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 2P30CA008748-43
  • Funding stream: NATIONAL CANCER INSTITUTE
,
NIH| Exosome-mediated Transfer of c-MET to Bone Marrow Progenitors Promotes Metastasis
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5R01CA169416-03
  • Funding stream: NATIONAL CANCER INSTITUTE
Communities
Neuroinformatics
51 references, page 1 of 4

Paget, S. The distribution of secondary growths in cancer of the breast. Cancer Metastasis Rev. 1989; 8: 98-101 [PubMed]

Hart, IR, Fidler, IJ. Role of organ selectivity in the determination of metastatic patterns of B16 melanoma. Cancer Res. 1980; 40: 2281-2287 [PubMed]

Müller, A. Involvement of chemokine receptors in breast cancer metastasis. Nature. 2001; 410: 50-56 [OpenAIRE] [PubMed]

Weilbaecher, KN, Guise, TA, McCauley, LK. Cancer to bone: a fatal attraction. Nature Rev Cancer. 2011; 11: 411-425 [OpenAIRE] [PubMed]

Zhou, W. Cancer-secreted miR-105 destroys vascular endothelial barriers to promote metastasis. Cancer Cell. 2014; 25: 501-515 [OpenAIRE] [PubMed]

Chang, Q. The IL-6/JAK/Stat3 feed-forward loop drives tumorigenesis and metastasis. Neoplasia. 2013; 15: 848-862 [OpenAIRE] [PubMed]

Lu, X, Kang, Y. Organotropism of breast cancer metastasis. J Mammary Gland Biol Neoplasia. 2007; 12: 153-162 [PubMed]

Cox, TR. The hypoxic cancer secretome induces pre-metastatic bone lesions through lysyl oxidase. Nature. 2015; 522: 106-110 [OpenAIRE] [PubMed]

Kaplan, RN. VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche. Nature. 2005; 438: 820-827 [OpenAIRE] [PubMed]

Hiratsuka, S. MMP9 induction by vascular endothelial growth factor receptor-1 is involved in lung-specifc metastasis. Cancer Cell. 2002; 2: 289-300 [OpenAIRE] [PubMed]

Peinado, H. Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET. Nature Med. 2012; 18: 883-891 [OpenAIRE] [PubMed]

Balaj, L. Tumour microvesicles contain retrotransposon elements and amplified oncogene sequences. Nature Commun. 2011; 2: 180 [OpenAIRE] [PubMed]

Skog, J. Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers. Nature Cell Biol. 2008; 10: 1470-1476 [OpenAIRE] [PubMed]

Théry, C, Ostrowski, M, Segura, E. Membrane vesicles as conveyors of immune responses. Nature Rev Immunol. 2009; 9: 581-593 [PubMed]

Raposo, G, Stoorvogel, W. Extracellular vesicles: exosomes, microvesicles, and friends. J Cell Biol. 2013; 200: 373-383 [OpenAIRE] [PubMed]

51 references, page 1 of 4
Abstract
© 2015 Macmillan Publishers Limited. All rights reserved. Ever since Stephen Paget's 1889 hypothesis, metastatic organotropism has remained one of cancer's greatest mysteries. Here we demonstrate that exosomes from mouse and human lung-, liver- and brain-tropic tumour cells fuse preferentially with resident cells at their predicted destination, namely lung fibroblasts and epithelial cells, liver Kupffer cells and brain endothelial cells. We show that tumour-derived exosomes uptaken by organ-specific cells prepare the pre-metastatic niche. Treatment with exosomes from lung-tropic models redirected the metastasis of bone-tropic tumour cells. Exosome proteomics rev...
Subjects
free text keywords: Liver, Lung, Brain, Cell Line, Tumor, Fibroblasts, Kupffer Cells, Endothelial Cells, Epithelial Cells, Animals, Mice, Inbred C57BL, Humans, Neoplasm Metastasis, S100 Proteins, Integrin alpha6beta1, Integrins, Integrin beta Chains, Integrin beta4, Integrin alpha6beta4, Receptors, Vitronectin, Organ Specificity, Tropism, Phosphorylation, Genes, src, Female, Exosomes, Biomarkers, Liver Disease, Cancer, Digestive Diseases, 2.1 Biological and endogenous factors, General Science & Technology, Article, Microvesicles, Exosome, medicine.disease, medicine, Liver cytology, Cell culture, Integrin, biology.protein, biology, Immunology, Cancer research, Metastasis
Funded by
NIH| Characterization and Functional Analysis of Breast Cancer Secreted Exosomes in Ma
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 1U01CA169538-01
  • Funding stream: NATIONAL CANCER INSTITUTE
,
NIH| MOUSE GENETICS
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 2P30CA008748-43
  • Funding stream: NATIONAL CANCER INSTITUTE
,
NIH| Exosome-mediated Transfer of c-MET to Bone Marrow Progenitors Promotes Metastasis
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5R01CA169416-03
  • Funding stream: NATIONAL CANCER INSTITUTE
Communities
Neuroinformatics
51 references, page 1 of 4

Paget, S. The distribution of secondary growths in cancer of the breast. Cancer Metastasis Rev. 1989; 8: 98-101 [PubMed]

Hart, IR, Fidler, IJ. Role of organ selectivity in the determination of metastatic patterns of B16 melanoma. Cancer Res. 1980; 40: 2281-2287 [PubMed]

Müller, A. Involvement of chemokine receptors in breast cancer metastasis. Nature. 2001; 410: 50-56 [OpenAIRE] [PubMed]

Weilbaecher, KN, Guise, TA, McCauley, LK. Cancer to bone: a fatal attraction. Nature Rev Cancer. 2011; 11: 411-425 [OpenAIRE] [PubMed]

Zhou, W. Cancer-secreted miR-105 destroys vascular endothelial barriers to promote metastasis. Cancer Cell. 2014; 25: 501-515 [OpenAIRE] [PubMed]

Chang, Q. The IL-6/JAK/Stat3 feed-forward loop drives tumorigenesis and metastasis. Neoplasia. 2013; 15: 848-862 [OpenAIRE] [PubMed]

Lu, X, Kang, Y. Organotropism of breast cancer metastasis. J Mammary Gland Biol Neoplasia. 2007; 12: 153-162 [PubMed]

Cox, TR. The hypoxic cancer secretome induces pre-metastatic bone lesions through lysyl oxidase. Nature. 2015; 522: 106-110 [OpenAIRE] [PubMed]

Kaplan, RN. VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche. Nature. 2005; 438: 820-827 [OpenAIRE] [PubMed]

Hiratsuka, S. MMP9 induction by vascular endothelial growth factor receptor-1 is involved in lung-specifc metastasis. Cancer Cell. 2002; 2: 289-300 [OpenAIRE] [PubMed]

Peinado, H. Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET. Nature Med. 2012; 18: 883-891 [OpenAIRE] [PubMed]

Balaj, L. Tumour microvesicles contain retrotransposon elements and amplified oncogene sequences. Nature Commun. 2011; 2: 180 [OpenAIRE] [PubMed]

Skog, J. Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers. Nature Cell Biol. 2008; 10: 1470-1476 [OpenAIRE] [PubMed]

Théry, C, Ostrowski, M, Segura, E. Membrane vesicles as conveyors of immune responses. Nature Rev Immunol. 2009; 9: 581-593 [PubMed]

Raposo, G, Stoorvogel, W. Extracellular vesicles: exosomes, microvesicles, and friends. J Cell Biol. 2013; 200: 373-383 [OpenAIRE] [PubMed]

51 references, page 1 of 4
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