Secondary progressive in contrast to relapsing-remitting multiple sclerosis patients show a normal CD4(+)CD25(+) regulatory T-Cell function and FOXP3 expression

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VENKEN, Koen; HELLINGS, Niels; Hensen, K; RUMMENS, Jean-Luc; MEDAER, Rob; D'hooghe, MB; Dubois, B; RAUS, Jef; STINISSEN, Piet;
(2006)
  • Publisher: Wiley
  • Related identifiers: doi: 10.1002/jnr.20852
  • Subject: CD4(+)CD25(+) regulatory T cells; multiple sclerosis; FOXP3
    mesheuropmc: chemical and pharmacologic phenomena | hemic and immune systems

Accumulating evidence indicates an immunosuppressive role for CD4(+)CD25(+) regulatory T cells (Tregs) in autoimmune diseases. Although an impaired Treg function in patients with relapsing-remitting multiple sclerosis (RR-MS) has been reported recently, no information i... View more
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