publication . Article . 2006

Secondary progressive in contrast to relapsing-remitting multiple sclerosis patients show a normal CD4(+)CD25(+) regulatory T-Cell function and FOXP3 expression

VENKEN, Koen; HELLINGS, Niels; Hensen, K; RUMMENS, Jean-Luc; MEDAER, Rob; D'hooghe, MB; Dubois, B; RAUS, Jef; STINISSEN, Piet;
Open Access English
  • Published: 01 Jan 2006
  • Publisher: Wiley
Abstract
Accumulating evidence indicates an immunosuppressive role for CD4(+)CD25(+) regulatory T cells (Tregs) in autoimmune diseases. Although an impaired Treg function in patients with relapsing-remitting multiple sclerosis (RR-MS) has been reported recently, no information is available so far about Treg function in the progressive stage of the disease. In the present study, the phenotypic and functional characteristics of CD4(+)CD25(+) T cells isolated from the peripheral blood of patients with RR-MS and secondary progressive multiple sclerosis (SP-MS) were investigated. No significant quantitative or phenotypic abnormalities in CD4(+)CD25(+) T cells from RR- and SP-...
Subjects
mesheuropmc: chemical and pharmacologic phenomenahemic and immune systems
free text keywords: CD4(+)CD25(+) regulatory T cells; multiple sclerosis; FOXP3
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publication . Article . 2006

Secondary progressive in contrast to relapsing-remitting multiple sclerosis patients show a normal CD4(+)CD25(+) regulatory T-Cell function and FOXP3 expression

VENKEN, Koen; HELLINGS, Niels; Hensen, K; RUMMENS, Jean-Luc; MEDAER, Rob; D'hooghe, MB; Dubois, B; RAUS, Jef; STINISSEN, Piet;