An ancestral role for the mitochondrial pyruvate carrier in glucose-stimulated insulin secretion

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McCommis, Kyle S.; Hodges, Wesley T.; Bricker, Daniel K.; Wisidagama, Dona R.; Compan, Vincent; Remedi, Maria S.; Thummel, Carl S.; Finck, Brian N.;
(2016)
  • Publisher: Elsevier BV
  • Journal: Molecular Metabolism,volume 5,issue 8,pages602-614 (issn: 2212-8778, eissn: 2212-8778)
  • Publisher copyright policies & self-archiving
  • Related identifiers: doi: 10.1016/j.molmet.2016.06.016, pmc: PMC5021712
  • Subject: MPC1 and MPC2 | Insulin-producing Cells | glucose tolerance test | Insulin | inner mitochondrial membrane | Drosophila insulin-like peptide 2 | IMM | Internal medicine | RESPYR, REporter Sensitive to PYRuvate | insulin tolerance test | Mitochondrial Pyruvate Carrier 1 and 2 | b-Cell | Original Article | pancreatic and duodenal homeobox 1 | oxygen consumption rates | Stimulus-coupled secretion | GSIS, glucose-stimulated insulin secretion | beta-Cell | Pdx1, pancreatic and duodenal homeobox 1 | Pdx1 | IPCs, Insulin-producing Cells | ITT, insulin tolerance test | OCR | RESPYR | Mitochondria | GSIS | GTT | IPCs | ITT | MPC1 and MPC2, Mitochondrial Pyruvate Carrier 1 and 2 | IMM, inner mitochondrial membrane | β-Cell | Pyruvate | glucose-stimulated insulin secretion | REporter Sensitive to PYRuvate | Drosophila | OCR, oxygen consumption rates | DILP2, Drosophila insulin-like peptide 2 | GTT, glucose tolerance test | [SDV]Life Sciences [q-bio] | RC31-1245 | DILP2 | Diabetes
    mesheuropmc: immune system diseases

Objective: Transport of pyruvate into the mitochondrial matrix by the Mitochondrial Pyruvate Carrier (MPC) is an important and rate-limiting step in its metabolism. In pancreatic β-cells, mitochondrial pyruvate metabolism is thought to be important for glucose sensing a... View more