Selenium-binding lactoferrin is taken into corneal epithelial cells by a receptor and prevents corneal damage in dry eye model animals

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Higuchi, Akihiro ; Inoue, Hiroyoshi ; Kaneko, Yoshio ; Oonishi, Erina ; Tsubota, Kazuo (2016)
  • Publisher: Nature Publishing Group
  • Journal: Scientific Reports, volume 6 (issn: 2045-2322, eissn: 2045-2322)
  • Related identifiers: pmc: PMC5105079, doi: 10.1038/srep36903
  • Subject: Article
    mesheuropmc: food and beverages | eye diseases | genetic structures | sense organs | fluids and secretions

The ocular surface is strongly affected by oxidative stress, which causes many ocular diseases including dry eye. Previously, we showed that selenium compounds, e.g., selenoprotein P and Se-lactoferrin, were candidates for treatment of dry eye. This paper shows the effi... View more
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