Fortifying the link between SIRT1, resveratrol and mitochondrial function
Article, Other literature type
Denu, John M.
- Publisher: Elsevier BV
Molecular Biology | Cell Biology | Physiology | Article
mesheuropmc: food and beverages | skin and connective tissue diseases | endocrine system diseases | organic chemicals | hormones, hormone substitutes, and hormone antagonists
The molecular mechanisms behind the health benefits of resveratrol remain enigmatic and controversial. Here, Price et al. establish a clear chemical-genetic connection between SIRT1 and resveratrol, providing strong evidence that SIRT1 is critical for resveratrol to stimulate mitochondrial biogenesis and a switch toward oxidative muscle fibers (Price et al., 2012).