Fortifying the link between SIRT1, resveratrol and mitochondrial function

Article, Other literature type English OPEN
Denu, John M. (2012)
  • Publisher: Elsevier BV
  • Journal: Cell Metabolism, volume 15, issue 5, pages 566-567 (issn: 1550-4131)
  • Related identifiers: doi: 10.1016/j.cmet.2012.04.016
  • Subject: Molecular Biology | Cell Biology | Physiology | Article
    mesheuropmc: food and beverages | skin and connective tissue diseases | endocrine system diseases | organic chemicals | hormones, hormone substitutes, and hormone antagonists

The molecular mechanisms behind the health benefits of resveratrol remain enigmatic and controversial. Here, Price et al. establish a clear chemical-genetic connection between SIRT1 and resveratrol, providing strong evidence that SIRT1 is critical for resveratrol to stimulate mitochondrial biogenesis and a switch toward oxidative muscle fibers (Price et al., 2012).
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