publication . Article . 2016

Adrenal-Derived Hormones Differentially Modulate Intestinal Immunity in Experimental Colitis

de Souza, Patrícia Reis; Sales-Campos, Helioswilton; Basso, Paulo José; Nardini, Viviani; Silva, Angelica; Banquieri, Fernanda; Alves, Vanessa Beatriz Freitas; Chica, Javier Emílio Lazo; Nomizo, Auro; Cardoso, Cristina Ribeiro de Barros;
Open Access English
  • Published: 01 Jun 2016 Journal: Mediators of Inflammation, volume 2,016 (issn: 0962-9351, eissn: 1466-1861, Copyright policy)
  • Publisher: Hindawi Publishing Corporation
Abstract
The adrenal glands are able to modulate immune responses through neuroimmunoendocrine interactions and cortisol secretion that could suppress exacerbated inflammation such as in inflammatory bowel disease (IBD). Therefore, here we evaluated the role of these glands in experimental colitis induced by 3% dextran sulfate sodium (DSS) in C57BL/6 mice subjected to adrenalectomy, with or without glucocorticoid (GC) replacement. Mice succumbed to colitis without adrenals with a higher clinical score and augmented systemic levels of IL-6 and lower LPS. Furthermore, adrenalectomy negatively modulated systemic regulatory markers. The absence of adrenals resulted in augmen...
Subjects
free text keywords: RB1-214, Pathology, Research Article, Article Subject
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publication . Article . 2016

Adrenal-Derived Hormones Differentially Modulate Intestinal Immunity in Experimental Colitis

de Souza, Patrícia Reis; Sales-Campos, Helioswilton; Basso, Paulo José; Nardini, Viviani; Silva, Angelica; Banquieri, Fernanda; Alves, Vanessa Beatriz Freitas; Chica, Javier Emílio Lazo; Nomizo, Auro; Cardoso, Cristina Ribeiro de Barros;