Zingerone Suppresses Liver Inflammation Induced by Antibiotic Mediated Endotoxemia through Down Regulating Hepatic mRNA Expression of Inflammatory Markers in Pseudomonas aeruginosa Peritonitis Mouse Model

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Lokender Kumar; Sanjay Chhibber; Kusum Harjai;
(2014)
  • Publisher: Public Library of Science
  • Journal: PLoS ONE,volume 9,issue 9 (issn: 1932-6203, eissn: 1932-6203)
  • Publisher copyright policies & self-archiving
  • Related identifiers: doi: 10.1371/journal.pone.0106536, pmc: PMC4159778
  • Subject: Molecular Biology | Research Article | Biology and Life Sciences | Gastroenterology and Hepatology | Microbiology | Medicine | Animal Models of Infection | Q | Medical Microbiology | R | Immunopathology | Immune Response | Inflammation | Clinical Immunology | Molecular Biology Techniques | Science | Liver Function Tests | Liver Diseases | Medicine and Health Sciences | Immunology

Antibiotic-induced endotoxin release is associated with high mortality rate even when appropriate antibiotics are used for the treatment of severe infections in intensive care units. Since liver is involved in systemic clearance and detoxification of endotoxin hence it ... View more
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