Protein structure and ionic selectivity in calcium channels: Selectivity filter size, not shape, matters

Article, Other literature type English OPEN
Malasics, Attila ; Gillespie, Dirk ; Nonner, Wolfgang ; Henderson, Douglas ; Eisenberg, Bob ; Boda, Dezső (2009)
  • Publisher: Elsevier BV
  • Journal: Biochimica et Biophysica Acta (BBA) - Biomembranes, volume 1,788, issue 12, pages 2,471-2,480 (issn: 0005-2736)
  • Related identifiers: doi: 10.1016/j.bbamem.2009.09.022, pmc: PMC2789594
  • Subject: Cell Biology | Biochemistry | Biophysics | Article

Calcium channels have highly charged selectivity filters (4 COO− groups) that attract cations in to balance this charge and minimize free energy, forcing the cations (Na+ and Ca2+) to compete for space in the filter. A reduced model was developed to better understand th... View more
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