Protein structure and ionic selectivity in calcium channels: Selectivity filter size, not shape, matters
Article, Other literature type
- Publisher: Elsevier BV
Biochimica et Biophysica Acta (BBA) - Biomembranes,
Cell Biology | Biochemistry | Biophysics | Article
Calcium channels have highly charged selectivity filters (4 COO− groups) that attract cations in to balance this charge and minimize free energy, forcing the cations (Na+ and Ca2+) to compete for space in the filter. A reduced model was developed to better understand th...