Tumor Repression of VCaP Xenografts by a Pyrrole-Imidazole Polyamide.

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Amanda E Hargrove; Thomas F Martinez; Alissa A Hare; Alexis A Kurmis; John W Phillips; Sudha Sud; Kenneth J Pienta; Peter B Dervan;

Pyrrole-imidazole (Py-Im) polyamides are high affinity DNA-binding small molecules that can inhibit protein-DNA interactions. In VCaP cells, a human prostate cancer cell line overexpressing both AR and the TMPRSS2-ERG gene fusion, an androgen response element (ARE)-targ... View more