Pinpointing Synaptic Loss Caused by Alzheimer’s Disease with fMRI

Article English OPEN
Adam M. Brickman; Scott A. Small; Adam Fleisher;
  • Publisher: Hindawi Limited
  • Journal: Behavioural Neurology,volume 21,issue 1-2,pages93-100 (issn: 0953-4180, eissn: 1875-8584)
  • Related identifiers: doi: 10.3233/BEN-2009-0240, pmc: PMC2857999
  • Subject: Research Article | Neurosciences. Biological psychiatry. Neuropsychiatry | RC321-571

During its earliest stage, before cell loss and independent of amyloid plaques and neurofibrillary tangles, Alzheimer's disease (AD) causes synaptic loss affecting the basal functional properties of neurons. In principle, synaptic loss can be detected by measuring AD-in... View more
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