Common variants of the BRCA1 wild-type allele modify the risk of breast cancer in BRCA1 mutation carriers

Article, Other literature type English OPEN
Cox, David G. ; Simard, Jacques ; Sinnett, Daniel ; Hamdi, Yosr ; Soucy, Penny ; Ouimet, Manon ; Barjhoux, Laure ; Verny-Pierre, Carole ; McGuffog, Lesley ; Healey, Sue ; Szabo, Csilla ; Greene, Mark H. ; Mai, Phuong L. ; Andrulis, Irene L. ; Thomassen, Mads ; Gerdes, Anne-Marie ; Caligo, Maria A. ; Friedman, Eitan ; Laitman, Yael ; Kaufman, Bella ; Paluch, Shani S. ; Borg, Ake ; Karlsson, Per ; Askmalm, Marie Stenmark ; Bustinza, Gisela Barbany ; Nathanson, Katherine L. ; Domchek, Susan M. ; Rebbeck, Timothy R. ; Benitez, Javier ; Hamann, Ute ... view all 109 authors (2011)
  • Publisher: OXFORD UNIV PRESS
  • Journal: HUMAN MOLECULAR GENETICS, volume 20, issue 23, pages 4,732-4,747 (issn: 0964-6906)
  • Related identifiers: pmc: PMC3733139, doi: 10.1093/hmg/ddr388
  • Subject: Association Studies Articles
    mesheuropmc: skin and connective tissue diseases | endocrine system diseases

Mutations in the BRCA1 gene substantially increase a woman's lifetime risk of breast cancer. However, there is great variation in this increase in risk with several genetic and non-genetic modifiers identified. The BRCA1 protein plays a central role in DNA repair, a mec... View more