Common variants of the BRCA1 wild-type allele modify the risk of breast cancer in BRCA1 mutation carriers.

Article, Other literature type English OPEN
Cox, D. G.; Simard, J.; Sinnett, D.; Hamdi, Y.; Soucy, P.; Ouimet, M.; Barjhoux, L.; Verny-Pierre, C.; McGuffog, L.; Healey, S.; Szabo, C.; Greene, M. H.; Mai, P. L.; Andrulis, I. L.; Thomassen, M.; Gerdes, A.-M.; Caligo, M. A.; Friedman, E.; Laitman, Y.; Kaufman, B.; Paluch, S. S.; Borg, A.; Karlsson, P.; Stenmark Askmalm, M.; Barbany Bustinza, G.; Nathanson, K. L.; Domchek, S. M.; Rebbeck, T. R.; Benitez, J.; Hamann, U.; ... view all 368 authors
(2011)
  • Publisher: Oxford University Press (OUP)
  • Journal: HUMAN MOLECULAR GENETICS,volume 20,issue 23,pages4,732-4,747 (issn: 0964-6906)
  • Publisher copyright policies & self-archiving
  • Related identifiers: pmc: PMC3733139, doi: 10.1093/hmg/ddr388
  • Subject: MESH: Genes, Reporter | MESH: Alleles | MESH: BRCA1 Protein | MESH : Genetic Association Studies | [ SDV.CAN ] Life Sciences [q-bio]/Cancer | MESH : Alleles | MESH : HeLa Cells | MESH : Genetic Predisposition to Disease | MESH : Electrophoretic Mobility Shift Assay | [SDV.CAN]Life Sciences [q-bio]/Cancer | MESH : Breast Neoplasms | MESH : Female | MESH: Female | MESH: HeLa Cells | MESH : Luciferases | MESH: Genetic Association Studies | MESH: Mutation | MESH : Linkage Disequilibrium | MESH: Genetic Predisposition to Disease | MESH : Risk Factors | MESH: Luciferases | MESH : Polymorphism, Single Nucleotide | MESH: Humans | MESH: Heterozygote | MESH: Breast Neoplasms | MESH: Electrophoretic Mobility Shift Assay | MESH: Linkage Disequilibrium | MESH : Genes, Reporter | MESH: Polymorphism, Single Nucleotide | MESH : Mutation | MESH : Haplotypes | MESH: Risk Factors | MESH : Humans | MESH : Heterozygote | Association Studies Articles | MESH: Haplotypes | MESH : BRCA1 Protein
    mesheuropmc: skin and connective tissue diseases | endocrine system diseases

International audience; Mutations in the BRCA1 gene substantially increase a woman's lifetime risk of breast cancer. However, there is great variation in this increase in risk with several genetic and non-genetic modifiers identified. The BRCA1 protein plays a central r... View more