Noisy: Identification of problematic columns in multiple sequence alignments

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Dress, Andreas WM; Flamm, Christoph; Fritzsch, Guido; Grünewald, Stefan; Kruspe, Matthias; Prohaska, Sonja J; Stadler, Peter F;
  • Publisher: BMC
  • Journal: Algorithms for Molecular Biology,volume 3,issue 1,pages7-7 (issn: 1748-7188, eissn: 1748-7188)
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  • Related identifiers: pmc: PMC2464588, doi: 10.1186/1748-7188-3-7
  • Subject: Molecular Biology | Applied Mathematics | QH426-470 | Phylogenetic Reconstruction, Cyclic Ordering, Balance Tree, Split System, Alignment Column | Genetics | Computational Theory and Mathematics | Software Article | Structural Biology | Biology (General) | QH301-705.5

<p>Abstract</p> <p>Motivation</p> <p>Sequence-based methods for phylogenetic reconstruction from (nucleic acid) sequence data are notoriously plagued by two effects: homoplasies and alignment errors. Large evolutionary distances imply a large number of homoplastic sites... View more
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