Structural basis of omalizumab therapy and omalizumab-mediated IgE exchange.
Pennington, Luke F
Graham, Michelle T
Nadeau, Kari Christine
Jardetzky, Theodore S
- Publisher: Nature Publishing Group
610 Medicine & health | Article
Omalizumab is a widely used therapeutic anti-IgE antibody. Here we report the crystal structure of the omalizumab–Fab in complex with an IgE-Fc fragment. This structure reveals the mechanism of omalizumab-mediated inhibition of IgE interactions with both high- and low-a...
55 references, page 1 of 6
views in local repository
downloads in local repository