Structural basis of omalizumab therapy and omalizumab-mediated IgE exchange.

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Pennington, Luke F ; Tarchevskaya, Svetlana ; Brigger, Daniel ; Sathiyamoorthy, Karthik ; Graham, Michelle T ; Nadeau, Kari Christine ; Eggel, Alexander ; Jardetzky, Theodore S (2016)

Omalizumab is a widely used therapeutic anti-IgE antibody. Here we report the crystal structure of the omalizumab–Fab in complex with an IgE-Fc fragment. This structure reveals the mechanism of omalizumab-mediated inhibition of IgE interactions with both high- and low-a... View more