Silvestrol exhibits significant in vivo and in vitro antileukemic activities and inhibits FLT3 and miR-155 expressions in acute myeloid leukemia

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Alachkar, Houda; Santhanam, Ramasamy; Harb, Jason G; Lucas, David M; Oaks, Joshua J; Hickey, Christopher J; Pan, Li; Kinghorn, A Douglas; Caligiuri, Michael A; Perrotti, Danilo; Byrd, John C; Garzon, Ramiro; Grever, Michael R; Marcucci, Guido;

Background Activating mutations [internal tandem duplication (ITD)] or overexpression of the FMS-like tyrosine kinase receptor-3 (FLT3) gene are associated with poor outcome in acute myeloid leukemia (AML) patients, underscoring the need for novel therapeutic approaches... View more