Blocking antibodies induced by immunization with a hypoallergenic parvalbumin mutant reduce allergic symptoms in a mouse model of fish allergy

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Freidl, Raphaela ; Gstoettner, Antonia ; Baranyi, Ulrike ; Swoboda, Ines ; Stolz, Frank ; Focke-Tejkl, Margarete ; Wekerle, Thomas ; van Ree, Ronald ; Valenta, Rudolf ; Linhart, Birgit (2016)
  • Publisher: Elsevier BV
  • Journal: The Journal of allergy and clinical immunology, volume 139, issue 6, pages 1,897-19,050 (issn: 0091-6749, eissn: 1097-6825)
  • Related identifiers: pmc: PMC5438872, doi: 10.1016/j.jaci.2016.10.018
  • Subject: fish allergy | Immunology and Allergy | Blocking antibodies | hypoallergenic parvalbumin mutant | specific immunotherapy | Immunology | Article
    mesheuropmc: respiratory system

Background Fish is a frequent elicitor of severe IgE-mediated allergic reactions. Beside avoidance, there is currently no allergen-specific therapy available. Hypoallergenic variants of the major fish allergen, parvalbumin, for specific immunotherapy based on mutation o... View more
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