Chicory (Cichorium intybus L.), which is known to have a variety of terpene-hydroxylating activities, was screened for a P450 mono-oxygenase to convert (+)-valencene to (+)-nootkatone. A novel P450 cDNA was identified in a chicory root EST library. Co-expression of the ... View more
 Faber, K. (2000) Biotransformations in Organic Chemistry: A Textbook, Springer, Berlin. pp. 220-272.
 Werck-Reichhart, D. and Feyereisen, R. (2000) Cytochromes P450: a sucess story. Genome Biol. 1, 3003.1-3003.9.
 Haring, H.G., Boelens, H., Vanderge, A. and Rijkens, F. (1972) Olfactory studies on enantiomeric eremophilane sesquiterpenoids. J. Agric. Food Chem. 20, 1018-1021.
 Delrio, J.A., Ortuno, A., Garciapuig, D., Porras, I., Garcialidon, A. and Sabater, F. (1992) Variations of nootkatone and valencene levels during the development of grapefruit. J. Agric. Food Chem. 40, 1488-1490.
 Fraatz, M.A., Berger, R.G. and Zorn, H. (2009) Nootkatone - a biotechnological challenge. Appl. Microbiol. Biotechnol. 83, 35-41.
 Hunter, G.L.K. and Brogden, W.B. (1965) Conversion of valencene to nootkatone. J. Food Sci. 30, 876-878.
 Wilson, C.W. and Shaw, P.E. (1978) Synthesis of nootkatone from valencene. J. Agric. Food Chem. 26, 1430-1432.
 Seifert, A., Vomund, S., Grohmann, K., Kriening, S., Urlacher, V.B., Laschat, S. and Pleiss, J. (2009) Rational design of a minimal and highly enriched CYP102A1 mutant library with improved regio-, stereo- and chemoselectivity. Chembiochem 10, 853-861.
 Sowden, R.J., Yasmin, S., Rees, N.H., Bell, S.G. and Wong, L.L. (2005) Biotransformation of the sesquiterpene (+)-valencene by cytochrome P450cam and P450BM-3. Org. Biomol. Chem. 3, 57-64.
 Takahashi, S., Yeo, Y.S., Zhao, Y., O'Maille, P.E., Greenhagen, B.T., Noel, J.P., Coates, R.M. and Chappell, J. (2007) Functional characterization of premnaspirodiene oxygenase, a cytochrome P450 catalyzing regio- and stereo-specific hydroxylations of diverse sesquiterpene substrates. J. Biol. Chem. 282, 31744-31754.