publication . Article . 2014

Role of Alveolar Macrophages in Chronic Obstructive Pulmonary Disease

Vlahos, Ross; Bozinovski, Steven;
Open Access English
  • Published: 10 Sep 2014 Journal: Frontiers in Immunology, volume 5 (issn: 1664-3224, eissn: 1664-3224, Copyright policy)
  • Publisher: Frontiers Media S.A.
Abstract
Alveolar macrophages (AMs) represent a unique leukocyte population that responds to airborne irritants and microbes. This distinct microenvironment coordinates the maturation of long-lived AMs, which originate from fetal blood monocytes and self-renew through mechanisms dependent on GM-CSF and CSF-1 signaling. Peripheral blood monocytes can also replenish lung macrophages; however, this appears to occur in a stimuli specific manner. In addition to mounting an appropriate immune response during infection and injury, AMs actively coordinate the resolution of inflammation through efferocytosis of apoptotic cells. Any perturbation of this process can lead to deleter...
Subjects
free text keywords: alveolar macrophage, Review Article, efferocytosis, Immunology, resolution, oxidative stress, chronic obstructive pulmonary disease, lung inflammation
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publication . Article . 2014

Role of Alveolar Macrophages in Chronic Obstructive Pulmonary Disease

Vlahos, Ross; Bozinovski, Steven;