Tor1a+/- mice develop dystonia-like movements via a striatal dopaminergic dysregulation triggered by peripheral nerve injury

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Ip, Chi Wang; Isaias, Ioannis U.; Kusche-Tekin, Burak B.; Klein, Dennis; Groh, Janos; O’Leary, Aet; Knorr, Susanne; Higuchi, Takahiro; Koprich, James B.; Brotchie, Jonathan M.; Toyka, Klaus V.; Reif, Andreas; Volkmann, Jens;
(2016)

Isolated generalized dystonia is a central motor network disorder characterized by twisted movements or postures. The most frequent genetic cause is a GAG deletion in the Tor1a (DYT1) gene encoding torsinA with a reduced penetrance of 30-40 % suggesting additional genet... View more