Gastrointestinal parasite control during prepuberty improves mammary parenchyma development in holstein heifers

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Perri, Adrián Francisco ; Mejía, Miguel E. ; Licoff, Nicolas ; Diab, Santiago ; Formía, Néstor ; Ornstein, Ana Maria ; Becu, Damasia ; Lacau Mengido, Isabel M. (2013)
  • Publisher: Elsevier Science Bv
  • Related identifiers: doi: 10.1016/j.vetpar.2013.09.006
  • Subject: CIENCIAS AGRÍCOLAS | Producción Animal y Lechería | Puberty | Producción Animal y Lechería (la Biotecnología Animal Va En 4.4 "biotecnología Agropecuaria") | Otras Producción Animal y Lechería | IGF-1 | Mammary development | Gastrointestinal parasites

Parasitism during development impairs normal growth and delays the onset of puberty through altered hormone profiles, including insulin-like growth factor one (IGF-1).Asmammary gland development during prepuberty is strongly dependent on IGF-1, we determined if antiparasitic treatment during this stage of growth improved mammary gland development. One group of Holstein heifers was treated monthly, rotationally with antiparasitic drugs from birth to 70 weeks of age, a second group was untreated. Treated heifer calves had between 56% and 65% less EPG counts than untreated ones. Presence of Ostertagia, Cooperia, Haemonchus and Trichostrongylus was demonstrated. Treatment effectively advanced the onset of puberty and increased IGF-1 levels. At 20, 30, 40 and 70 weeks of age biopsies from the mammary gland were taken and histological sections were prepared and stained with hematoxylin–eosin. Pictures were analyzed to compare parenchyma area in relation to total mammary tissue between groups. Mammary samples from treated heifers had higher ratios of parenchyma/total area than untreated ones. As mammary development during prepuberty is crucial for mammary performance during lactation, these results add new evidence to the importance of gastrointestinal parasite control in heifers Fil: Perri, Adrián Francisco. Universidad Nacional del Litoral; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina Fil: Mejía, Miguel E.. Universidad Nacional del Litoral; Argentina Fil: Licoff, Nicolas. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina Fil: Diab, Santiago. University of California; Estados Unidos Fil: Formía, Néstor. Universidad Nacional de La Plata; Argentina Fil: Ornstein, Ana Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina Fil: Becu, Damasia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina Fil: Lacau Mengido, Isabel M.. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina