publication . Article . 2016

Constrained multivariate association with longitudinal phenotypes

Phillip Melton; Jm, Peralta; Almasy L;
Open Access
  • Published: 01 Oct 2016 Journal: BMC Proceedings, volume 10 (eissn: 1753-6561, Copyright policy)
  • Publisher: Springer Nature
Abstract
Background The incorporation of longitudinal data into genetic epidemiological studies has the potential to provide valuable information regarding the effect of time on complex disease etiology. Yet, the majority of research focuses on variables collected from a single time point. This aim of this study was to test for main effects on a quantitative trait across time points using a constrained maximum-likelihood measured genotype approach. This method simultaneously accounts for all repeat measurements of a phenotype in families. We applied this method to systolic blood pressure (SBP) measurements from three time points using the Genetic Analysis Workshop 19 (GA...
Subjects
free text keywords: Pedigree chart, Bioinformatics, Bivariate analysis, Multivariate statistics, Genetics, Time point, Quantitative trait locus, Genetic analysis, Kernel (linear algebra), Trait, Medicine, business.industry, business, Proceedings
Related Organizations
Funded by
NIH| Genetic Analysis of Common Diseases: An Evaluation
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5R01GM031575-22
  • Funding stream: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

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