Preparation of Starch/Gelatin Blend Microparticles by a Water-in-Oil Emulsion Method for Controlled Release Drug Delivery

Article English OPEN
Theeraphol Phromsopha ; Yodthong Baimark (2014)
  • Publisher: Hindawi Limited
  • Journal: International Journal of Biomaterials, volume 2,014 (issn: 1687-8787, eissn: 1687-8795)
  • Related identifiers: doi: 10.1155/2014/829490, pmc: PMC4020388
  • Subject: Biotechnology | Research Article | Article Subject | TP248.13-248.65
    mesheuropmc: food and beverages | education | macromolecular substances | technology, industry, and agriculture

Information on the preparation and properties of starch/gelatin blend microparticles with and without crosslinking for drug delivery is presented. The blend microparticles were prepared by the water-in-oil emulsion solvent diffusion method. Glutaraldehyde and methylene blue were used as the crosslinker and the water-soluble drug model, respectively. The blend microparticles were characterized by scanning electron microscopy (SEM), Fourier transform infrared (FTIR) spectroscopy, and UV-Vis spectroscopy. The functional groups of the starch and gelatin blend matrices were determined from the FTIR spectra. Blend microparticles with a nearly spherical shape and internal porous structure were observed from SEM images. The average particle size of the gelatin microparticles depended on the crosslinker ratio but not on the starch/gelatin blend ratio. The in vitro drug release content significantly decreased as the crosslinker ratio increased and the starch blend ratio decreased. The results demonstrated that the starch/gelatin blend microparticles should be a useful controlled release delivery carrier for water-soluble drugs.
  • References (20)
    20 references, page 1 of 2

    Stolnik, S., Illum, L., Davis, S. S.. Long circulating microparticulate drug carriers. Advanced Drug Delivery Reviews. 1995; 16 (2-3): 195-214

    Freitas, S., Merkle, H. P., Gander, B.. Microencapsulation by solvent extraction/evaporation: reviewing the state of the art of microsphere preparation process technology. Journal of Controlled Release. 2005; 102 (2): 313-332

    Barea, M. J., Jenkins, M. J., Lee, Y. S., Johnson, P., Bridson, R. H.. Encapsulation of liposomes within pH responsive microspheres for oral colonic drug delivery. International Journal of Biomaterials. 2012; 2012-8

    Baimark, Y., Srisuwan, Y.. Preparation of polysaccharide-based microspheres by a water-in-oil emulsion solvent diffusion method for drug carriers. International Journal of Polymer Science. 2013; 2013-6

    Dainiak, M. B., Allan, I. U., Savina, I. N., Cornelio, L., James, E. S., James, S. L., Mikhalovsky, S. V., Jungvid, H., Galaev, I. Y.. Gelatin-fibrinogen cryogel dermal matrices for wound repair: preparation, optimisation and in vitro study. Biomaterials. 2010; 31 (1): 67-76

    Huang, K.-S., Lu, K., Yeh, C.-S., Chung, S.-R., Lin, C.-H., Yang, C.-H., Dong, Y.-S.. Microfluidic controlling monodisperse microdroplet for 5-fluorouracil loaded genipin-gelatin microcapsules. Journal of Controlled Release. 2009; 137 (1): 15-19

    Saravanan, M., Bhaskar, K., Maharajan, G., Pillai, K. S.. Development of gelatin microspheres loaded with diclofenac sodium for intra-articular administration. Journal of Drug Targeting. 2011; 19 (2): 96-103

    Sun, R., Shi, J., Guo, Y., Chen, L.. Studies on the particle size control of gelatin microspheres. Frontiers of Chemistry in China. 2009; 4 (2): 222-228

    Nakamatsu, J., Torres, F. G., Troncoso, O. P., Min-Lin, Y., Boccaccini, A. R.. Processing and characterization of porous structures from chitosan and starch for tissue engineering scaffolds. Biomacromolecules. 2006; 7 (12): 3345-3355

    Bajpai, A. K., Bhanu, S.. Dynamics of controlled release of heparin from swellable crosslinked starch microspheres. Journal of Materials Science: Materials in Medicine. 2007; 18 (8): 1613-1621

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