Cancer incidence and survival in Lynch syndrome patients receiving colonoscopic and gynaecological surveillance: first report from the prospective Lynch syndrome database

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Møller, Pål; Seppälä, Toni; Bernstein, Inge; Holinski-Feder, Elke; Sala, Paola; Evans, D. Gareth; Lindblom, Annika; Macrae, Finlay; Blanco, Ignacio; Sijmons, Rolf; Jeffries, Jacqueline; Vasen, Hans; Burn, John; Nakken, Sigve; Hovig, Eivind; Rødland, Einar Andreas; Tharmaratnam, Kukatharmini; de Vos tot Nederveen Cappel, Wouter H.; Hill, James; Wijnen, Juul; Green, Kate; Lalloo, Fiona; Sunde, Lone; Mints, Miriam; Bertario, Lucio; Pineda, Marta; Navarro, Matilde; Morak, Monika; Renkonen-Sinisalo, Laura; Frayling, Ian; ... view all 36 authors
(2017)
  • Publisher: BMJ Publishing Group Ltd
  • Journal: volume 66,issue 3,pages464-472issn: 0017-5749, eissn: 1468-3288
  • Publisher copyright policies & self-archiving
  • Related identifiers: pmc: PMC5534760, doi: 10.1136/gutjnl-2015-309675
  • Subject: ADENOMAS | RC0254 | NONPOLYPOSIS COLORECTAL-CANCER | COLORECTAL CANCER | CANCER PREVENTION | MSH2 MUTATION | IMPACT | MISMATCH REPAIR | FAMILIES | 3121 Internal medicine | CANCER GENETICS | MUTATION CARRIERS | MANAGEMENT | Colon | GUIDELINES | CANCER SYNDROMES | RISK | 1506 | COLONOSCOPY
    mesheuropmc: congenital, hereditary, and neonatal diseases and abnormalities | digestive system diseases | nutritional and metabolic diseases | neoplasms

Objective Estimates of cancer risk and the effects of surveillance in Lynch syndrome have been subject to bias, partly through reliance on retrospective studies. We sought to establish more robust estimates in patients undergoing prospective cancer surveillance.\ud \ud ... View more
  • References (29)
    29 references, page 1 of 3

    1 Vasen HF, Blanco I, Aktan-Collan K, et al. Revised guidelines for the clinical management of Lynch syndrome (HNPCC): recommendations by a group of European experts. Gut 2013;62:812-23.

    2 Giardiello FM, Allen JI, Axilbund JE, et al. Guidelines on genetic evaluation and management of Lynch syndrome: a consensus statement by the US Multi-society Task Force on colorectal cancer. Am J Gastroenterol 2014;109:1159-79.

    3 Stormorken AT, Clark N, Grindedal E, et al. Prevention of colorectal cancer by colonoscopic surveillance in families with hereditary colorectal cancer. Scand J Gastroenterol 2007;42:611-17.

    6 7 Järvinen HJ, Renkonen-Sinisalo L, Aktán-Collán K, et al. Ten years after mutation testing for Lynch syndrome: cancer incidence and outcome in mutation-positive and mutation-negative family members. J Clin Oncol 2009;27:4793-7.

    Engel C, Rahner N, Schulmann K, et al. Efficacy of annual colonoscopic surveillance in individuals with hereditary nonpolyposis colorectal cancer. Clin Gastroenterol Hepatol 2010;8:174-82.

    Vasen HF, Abdirahman M, Brohet R, et al. One to 2-year surveillance intervals reduce risk of colorectal cancer in families with Lynch syndrome. Gastroenterology 2010;138:2300-6.

    Burn J, Gerdes AM, Macrae F, et al. Long-term effect of aspirin on cancer risk in carriers of hereditary colorectal cancer: an analysis from the CAPP2 randomised controlled trial. Lancet 2011;378:2081-7.

    Stuckless S, Green JS, Morgenstern M, et al. Impact of colonoscopic screening in male and female Lynch syndrome carriers with an MSH2 mutation. Clin Genet 2012;82:439-45.

    Snowsill T, Huxley N, Hoyle M, et al. A systematic review and economic evaluation of diagnostic strategies for Lynch syndrome. Health Technol Assess 2014;58:1-406.

    Newton K, Green K, Lalloo F, et al. Colonoscopy screening compliance and outcomes in patients with Lynch syndrome. Colorectal Dis 2015;17:38-46.

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