Cancer incidence and survival in Lynch syndrome patients receiving colonoscopic and gynaecological surveillance: first report from the prospective Lynch syndrome database

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Møller, Pål ; Seppälä, Toni ; Bernstein, Inge ; Holinski-Feder, Elke ; Sala, Paola ; Evans, D. Gareth ; Lindblom, Annika ; Macrae, Finlay ; Blanco, Ignacio ; Sijmons, Rolf ; Jeffries, Jacqueline ; Vasen, Hans ; Burn, John ; Nakken, Sigve ; Hovig, Eivind ; Rødland, Einar Andreas ; Tharmaratnam, Kukatharmini ; de Vos tot Nederveen Cappel, Wouter H. ; Hill, James ; Wijnen, Juul ; Green, Kate ; Lalloo, Fiona ; Sunde, Lone ; Mints, Miriam ; Bertario, Lucio ; Pineda, Marta ; Navarro, Matilde ; Morak, Monika ; Renkonen-Sinisalo, Laura ; Frayling, Ian ... view all 36 authors (2017)
  • Publisher: BMJ Publishing Group Ltd
  • Journal: volume 66, issue 3, pages 464-472 (issn: 0017-5749, eissn: 1468-3288)
  • Related identifiers: doi: 10.1136/gutjnl-2015-309675, pmc: PMC5534760
    mesheuropmc: congenital, hereditary, and neonatal diseases and abnormalities | digestive system diseases | neoplasms | nutritional and metabolic diseases

Objective Estimates of cancer risk and the effects of surveillance in Lynch syndrome have been subject to bias, partly through reliance on retrospective studies. We sought to establish more robust estimates in patients undergoing prospective cancer surveillance.\ud \ud ... View more
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