Linked mutations at adjacent nucleotides have shaped human population differentiation and protein evolution

Article English OPEN
Prendergast, James G D; Pugh, Carys; Harris, Sarah E; Hume, David A; Deary, Ian J; Beveridge, Allan;
(2019)
  • Publisher: Oxford University Press
  • Journal: volume 11,issue 3,pages759-775eissn: 1759-6653
  • Publisher copyright policies & self-archiving
  • Related identifiers: pmc: PMC6424222, doi: 10.1093/gbe/evz014
  • Subject: human mutation | multinucleotide polymorphisms | Research Article | multi-nucleotide mutations | sequential dinucleotide mutations | multinucleotide mutations | DNA repair | SDM | MNP | sequential dinucleotide mutations, | epistatic selection | multi-nucleotide polymorphisms

Abstract Despite the fundamental importance of single nucleotide polymorphisms (SNPs) to human evolution, there are still large gaps in our understanding of the forces that shape their distribution across the genome. SNPs have been shown to not be distributed evenly, wi... View more
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