publication . Article . 2015

Multidrug Efflux Systems in Microaerobic and Anaerobic Bacteria

Zeling Xu; Aixin Yan;
Open Access English
  • Published: 01 Aug 2015 Journal: Antibiotics, volume 4, issue 3, pages 379-396 (issn: 2079-6382, eissn: 2079-6382, Copyright policy)
  • Publisher: MDPI
Abstract
Active drug efflux constitutes an important mechanism of antibiotic and multidrug resistance in bacteria. Understanding the distribution, expression, and physiological functions of multidrug efflux pumps, especially under physiologically and clinically relevant conditions of the pathogens, is the key to combat drug resistance. In animal hosts, most wounded, infected and inflamed tissues display low oxygen tensions. In this article, we summarize research development on multidrug efflux pumps in the medicinally relevant microaerobic and anaerobic pathogens and their implications in the effort to combat drug-resistant infections.
Subjects
free text keywords: RM1-950, anaerobic bacteria, Therapeutics. Pharmacology, Review, multi-drug efflux pump, efflux pump inhibitors, microaerobic bacteria
95 references, page 1 of 7

Poole, K.. Efflux pumps as antimicrobial resistance mechanisms. Ann. Med.. 2007; 39: 162-176 [PubMed] [DOI]

Hirakawa, H., Inazumi, Y., Senda, Y., Kobayashi, A., Hirata, T., Nishino, K., Yamaguchi, A.. N-Acetyl-d-Glucosamine induces the expression of multidrug exporter genes, mdtEF, via catabolite activation in Escherichiacoli. J. Bacteriol.. 2006; 188: 5851-5858 [OpenAIRE] [PubMed] [DOI]

Piddock, L.J.. Multidrug-resistance efflux pumps—Not just for resistance. Nat. Rev. Microbiol.. 2004; 4: 629-636 [PubMed] [DOI]

Jantsch, J., Schodel, J.. Hypoxia and hypoxia-inducible factors in myeloid cell-driven host defense and tissue homeostasis. Immunobiology. 2015; 220: 305-314 [PubMed] [DOI]

Marteyn, B., Scorza, F.B., Sansonetti, P.J., Tang, C.. Breathing life into pathogens: The influence of oxygen on bacterial virulence and host responses in the gastrointestinal tract. Cell Microbiol.. 2011; 13: 171-176 [PubMed] [DOI]

Sun, J., Deng, Z., Yan, A.. Bacterial multidrug efflux pumps: Mechanisms, physiology and pharmacological exploitations. Biochem. Biophys. Res. Commun.. 2014; 453: 254-267 [OpenAIRE] [PubMed] [DOI]

Putman, M., Veen, H.W., Konings, W.. Molecular properties of bacterial multidrug transporters. Microbiol. Mol. Biol. Rev.. 2000; 64: 672-693 [OpenAIRE] [PubMed] [DOI]

Perera, I.C., Grove, A.. Molecular mechanisms of ligand-mediated attenuation of DNA binding by MarR family transcriptional regulators. J. Mol. Cell Biol.. 2010; 2: 243-254 [PubMed] [DOI]

Brown, N.L., Stoyanov, J.V., Kidd, S.P., Hobman, J.L.. The MerR family of transcriptional regulators. FEMS Microbiol. Rev.. 2003; 27: 145-163 [PubMed] [DOI]

Ramos, J.L., Martinez-Bueno, M., Molina-Henares, A.J., Teran, W., Watanabe, K., Zhang, X., Gallegos, M.T., Brennan, R., Tobes, R.. The TetR family of transcriptional repressors. Microbiol. Mol. Biol. Rev.. 2005; 69: 326-356 [OpenAIRE] [PubMed] [DOI]

Nikaido, E., Shirosaka, I., Yamaguchi, A., Nishino, K.. Regulation of the AcrAB multidrug efflux pump in Salmonella enterica serovar Typhimurium in response to indole and paraquat. Microbiology. 2011; 157: 648-655 [PubMed] [DOI]

Hoch, J.A.. Two-component and phosphorelay signal transduction. Curr. Opin. Microbiol.. 2000; 3: 165-170 [PubMed] [DOI]

Baranova, N., Nikaido, H.. The BaeSR two-component regulatory system activates transcription of the yegMNOB (mdtABCD) transporter gene cluster in Escherichia coli and increases its resistance to novobiocin and deoxycholate. J. Bacteriol.. 2002; 184: 4168-4176 [OpenAIRE] [PubMed] [DOI]

Akiba, M., Lin, J., Barton, Y.W., Zhang, Q.. Interaction of CmeABC and CmeDEF in conferring antimicrobial resistance and maintaining cell viability in Campylobacter jejuni. J. Antimicrob. Chemoth.. 2006; 57: 52-60 [PubMed] [DOI]

Lin, J., Akiba, M., Sahin, O., Zhang, Q.. CmeR functions as a transcriptional repressor for the multidrug efflux pump CmeABC in Campylobacter jejuni. Antimicrob. Agents Chemother.. 2005; 49: 1067-1075 [OpenAIRE] [PubMed] [DOI]

95 references, page 1 of 7
Abstract
Active drug efflux constitutes an important mechanism of antibiotic and multidrug resistance in bacteria. Understanding the distribution, expression, and physiological functions of multidrug efflux pumps, especially under physiologically and clinically relevant conditions of the pathogens, is the key to combat drug resistance. In animal hosts, most wounded, infected and inflamed tissues display low oxygen tensions. In this article, we summarize research development on multidrug efflux pumps in the medicinally relevant microaerobic and anaerobic pathogens and their implications in the effort to combat drug-resistant infections.
Subjects
free text keywords: RM1-950, anaerobic bacteria, Therapeutics. Pharmacology, Review, multi-drug efflux pump, efflux pump inhibitors, microaerobic bacteria
95 references, page 1 of 7

Poole, K.. Efflux pumps as antimicrobial resistance mechanisms. Ann. Med.. 2007; 39: 162-176 [PubMed] [DOI]

Hirakawa, H., Inazumi, Y., Senda, Y., Kobayashi, A., Hirata, T., Nishino, K., Yamaguchi, A.. N-Acetyl-d-Glucosamine induces the expression of multidrug exporter genes, mdtEF, via catabolite activation in Escherichiacoli. J. Bacteriol.. 2006; 188: 5851-5858 [OpenAIRE] [PubMed] [DOI]

Piddock, L.J.. Multidrug-resistance efflux pumps—Not just for resistance. Nat. Rev. Microbiol.. 2004; 4: 629-636 [PubMed] [DOI]

Jantsch, J., Schodel, J.. Hypoxia and hypoxia-inducible factors in myeloid cell-driven host defense and tissue homeostasis. Immunobiology. 2015; 220: 305-314 [PubMed] [DOI]

Marteyn, B., Scorza, F.B., Sansonetti, P.J., Tang, C.. Breathing life into pathogens: The influence of oxygen on bacterial virulence and host responses in the gastrointestinal tract. Cell Microbiol.. 2011; 13: 171-176 [PubMed] [DOI]

Sun, J., Deng, Z., Yan, A.. Bacterial multidrug efflux pumps: Mechanisms, physiology and pharmacological exploitations. Biochem. Biophys. Res. Commun.. 2014; 453: 254-267 [OpenAIRE] [PubMed] [DOI]

Putman, M., Veen, H.W., Konings, W.. Molecular properties of bacterial multidrug transporters. Microbiol. Mol. Biol. Rev.. 2000; 64: 672-693 [OpenAIRE] [PubMed] [DOI]

Perera, I.C., Grove, A.. Molecular mechanisms of ligand-mediated attenuation of DNA binding by MarR family transcriptional regulators. J. Mol. Cell Biol.. 2010; 2: 243-254 [PubMed] [DOI]

Brown, N.L., Stoyanov, J.V., Kidd, S.P., Hobman, J.L.. The MerR family of transcriptional regulators. FEMS Microbiol. Rev.. 2003; 27: 145-163 [PubMed] [DOI]

Ramos, J.L., Martinez-Bueno, M., Molina-Henares, A.J., Teran, W., Watanabe, K., Zhang, X., Gallegos, M.T., Brennan, R., Tobes, R.. The TetR family of transcriptional repressors. Microbiol. Mol. Biol. Rev.. 2005; 69: 326-356 [OpenAIRE] [PubMed] [DOI]

Nikaido, E., Shirosaka, I., Yamaguchi, A., Nishino, K.. Regulation of the AcrAB multidrug efflux pump in Salmonella enterica serovar Typhimurium in response to indole and paraquat. Microbiology. 2011; 157: 648-655 [PubMed] [DOI]

Hoch, J.A.. Two-component and phosphorelay signal transduction. Curr. Opin. Microbiol.. 2000; 3: 165-170 [PubMed] [DOI]

Baranova, N., Nikaido, H.. The BaeSR two-component regulatory system activates transcription of the yegMNOB (mdtABCD) transporter gene cluster in Escherichia coli and increases its resistance to novobiocin and deoxycholate. J. Bacteriol.. 2002; 184: 4168-4176 [OpenAIRE] [PubMed] [DOI]

Akiba, M., Lin, J., Barton, Y.W., Zhang, Q.. Interaction of CmeABC and CmeDEF in conferring antimicrobial resistance and maintaining cell viability in Campylobacter jejuni. J. Antimicrob. Chemoth.. 2006; 57: 52-60 [PubMed] [DOI]

Lin, J., Akiba, M., Sahin, O., Zhang, Q.. CmeR functions as a transcriptional repressor for the multidrug efflux pump CmeABC in Campylobacter jejuni. Antimicrob. Agents Chemother.. 2005; 49: 1067-1075 [OpenAIRE] [PubMed] [DOI]

95 references, page 1 of 7
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publication . Article . 2015

Multidrug Efflux Systems in Microaerobic and Anaerobic Bacteria

Zeling Xu; Aixin Yan;