Reduction of lung metastasis, cell invasion, and adhesion in mouse melanoma by statin-induced blockade of the Rho/Rho-associated coiled-coil-containing protein kinase pathway

Article English OPEN
Kidera, Yasuhiro ; Tsubaki, Masanobu ; Yamazoe, Yuzuru ; Shoji, Kaori ; Nakamura, Haruyuki ; Ogaki, Mitsuhiko ; Satou, Takao ; Itoh, Tatsuki ; Isozaki, Misako ; Kaneko, Junichi ; Tanimori, Yoshihiro ; Yanae, Masashi ; Nishida, Shozo (2010)
  • Publisher: BioMed Central
  • Journal: Journal of Experimental & Clinical Cancer Research : CR, volume 29, issue 1, pages 127-127 (issn: 0392-9078, eissn: 1756-9966)
  • Related identifiers: doi: 10.1186/1756-9966-29-127, pmc: PMC2949822
  • Subject: RC254-282 | Research | Neoplasms. Tumors. Oncology. Including cancer and carcinogens

<p>Abstract</p> <p>Background</p> <p>Melanomas are highly malignant and have high metastatic potential; hence, there is a need for new therapeutic strategies to prevent cell metastasis. In the present study, we investigated whether statins inhibit tumor cell migration, ... View more
Share - Bookmark