Reduction of lung metastasis, cell invasion, and adhesion in mouse melanoma by statin-induced blockade of the Rho/Rho-associated coiled-coil-containing protein kinase pathway

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Kidera, Yasuhiro; Tsubaki, Masanobu; Yamazoe, Yuzuru; Shoji, Kaori; Nakamura, Haruyuki; Ogaki, Mitsuhiko; Satou, Takao; Itoh, Tatsuki; Isozaki, Misako; Kaneko, Junichi; Tanimori, Yoshihiro; Yanae, Masashi; Nishida, Shozo;
  • Publisher: BioMed Central
  • Journal: Journal of Experimental & Clinical Cancer Research : CR,volume 29,issue 1,pages127-127 (issn: 0392-9078, eissn: 1756-9966)
  • Related identifiers: doi: 10.1186/1756-9966-29-127, pmc: PMC2949822
  • Subject: Research

Background Melanomas are highly malignant and have high metastatic potential; hence, there is a need for new therapeutic strategies to prevent cell metastasis. In the present study, we investigated whether statins inhibit tumor cell migration, invasion, adhesion, and me... View more
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