publication . Article . Other literature type . 2018

Ano-rectal wall dose-surface maps localize the dosimetric benefit of hydrogel rectum spacers in prostate cancer radiotherapy

Vanneste, Ben G.L.; Buettner, Florian; Pinkawa, Michael; Lambin, Philippe; Hoffmann, Aswin L.;
Open Access
  • Published: 01 Nov 2018
Abstract
Background and purpose To evaluate spatial differences in dose distributions of the ano-rectal wall (ARW) using dose-surface maps (DSMs) between prostate cancer patients receiving intensity-modulated radiation therapy with and without implantable rectum spacer (IMRT+IRS; IMRT−IRS, respectively), and to correlate this with late gastro-intestinal (GI) toxicities using validated spatial and non-spatial normal-tissue complication probability (NTCP) models. Materials and methods For 26 patients DSMs of the ARW were generated. From the DSMs various shape-based dose measures were calculated at different dose levels: lateral extent, longitudinal extent, and eccentricity...
Subjects
free text keywords: Prostate cancer, Radiotherapy, Rectum spacer, Dose-surface maps, Toxicity reduction, QUALITY-OF-LIFE, POLYETHYLENE-GLYCOL HYDROGEL, MODULATED RADIATION-THERAPY, GASTROINTESTINAL TOXICITY, CONFORMAL RADIOTHERAPY, BALLOON, TRIAL, BRACHYTHERAPY, HISTOGRAMS, REDUCTION, Article, Medical physics. Medical radiology. Nuclear medicine, R895-920, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
57 references, page 1 of 4

Glass, A.S., Cowan, J.E., Fuldeore, M.J., Cooperberg, M.R., Carroll, P.R., Kenfield, S.A.. Patient demographics, quality of life, and disease features of men with newly diagnosed prostate cancer: trends in the PSA era. Urology. 2013; 82 (1): 60-65 [PubMed]

Krol, R., Smeenk, R.J., van Lin, E.N., Hopman, W.P.. Impact of late anorectal dysfunction on quality of life after pelvic radiotherapy. Int J Colorectal Dis. 2013; 28 (4): 519-526 [PubMed]

Vanneste, B.G., Van De Voorde, L., de Ridder, R.J., Van Limbergen, E.J., Lambin, P., van Lin, E.N.. Chronic radiation proctitis: tricks to prevent and treat. Int J Colorectal Dis. 2015; 30 (10): 1293-1303 [OpenAIRE] [PubMed]

Smeenk, R.J., Van Lin, E.N.J.T.. Application of anorectal sparing devices in prostate radiotherapy. Radiother Oncol. 2013; 106 (2): 155-156 [PubMed]

Pinkawa, M., Corral, N.E., Caffaro, M.. Application of a spacer gel to optimize three-dimensional conformal and intensity modulated radiotherapy for prostate cancer. Radiother Oncol. 2011; 100 (3): 436-441 [OpenAIRE] [PubMed]

Prada, P.J., Fernández, J., Martinez, A.A., de la Rúa, A., Gonzalez, J.M., Fernandez, J.M.. Transperineal injection of hyaluronic acid in anterior perirectal fat to decrease rectal toxicity from radiation delivered with intensity modulated brachytherapy or EBRT for prostate cancer patients. Int J Radiat Oncol Biol Phys. 2007; 69 (1): 95-102 [PubMed]

Melchert, C.. Interstitial biodegradable balloon for reduced rectal dose during prostate radiotherapy: results of a virtual planning investigation based on the pre- and post-implant imaging data of an international multicenter study. Radiother Oncol. 2013; 106 (2): 210-214 [OpenAIRE] [PubMed]

Noyes, W.R., Hosford, C.C., Schultz, S.E.. Human collagen injections to reduce rectal dose during radiotherapy. Int J Radiat Oncol Biol Phys. 2012; 82 (5): 1918-1922 [PubMed]

Vanneste, B.G., van De Beek, K., Lutgens, L., Lambin, P.. Implantation of a biodegradable rectum balloon implant: tips, Tricks and Pitfalls. Int Braz J Urol. 2017; 24: 43

Vanneste, B.G.L., van wijk, Y., Lutgens, L.C., Van Limbergen, E.J., van Lin, E.N., van de Beek, K.. Dynamics of rectal balloon implant shrinkage do not affect anorectal dose and late rectal complication risk in prostate VMAT. Strahlenther Onkol. 2018; 194 (1): 31-40 [OpenAIRE] [PubMed]

Song, D.Y.. A multi-institutional clinical trial of rectal dose reduction via injected polyethylene-glycol hydrogel during intensity modulated radiation therapy for prostate cancer: analysis of dosimetric outcomes. Int J Radiat Oncol Biol Phys. 2013; 87 (1): 81-87 [OpenAIRE] [PubMed]

Strom, T.J.. A dosimetric study of polyethylene glycol hydrogel in 200 prostate cancer patients treated with high-dose rate brachytherapy ± intensity modulated radiation therapy. Radiother Oncol. 2014; 111 (1): 126-131 [PubMed]

Habl, G.. Acute toxicity and quality of life in patients with prostate cancer treated with protons or carbon ions in a prospective randomized phase II study-the IPI trial. Int J Radiat Oncol Biol Phys.. 2016; 95 (1): 435-443 [OpenAIRE] [PubMed]

Fagundes, M., Han-Chih Chang, J., Michalski, J., Soffen, E., Davis, B., Pisansky, T.. In Regard to Habl et al.. Int J Radiat Oncol Biol Phys. 2016; 96 (1): 241-242 [PubMed]

Mariados, N.. hydrogel spacer prospective multicenter randomized controlled pivotal trial: dosimetric and clinical effects of perirectal spacer application in men undergoing prostate image guided intensity modulated radiation therapy. Int J Radiat Oncol Biol Phys. 2015; 92 (5): 971-977 [OpenAIRE] [PubMed]

57 references, page 1 of 4
Abstract
Background and purpose To evaluate spatial differences in dose distributions of the ano-rectal wall (ARW) using dose-surface maps (DSMs) between prostate cancer patients receiving intensity-modulated radiation therapy with and without implantable rectum spacer (IMRT+IRS; IMRT−IRS, respectively), and to correlate this with late gastro-intestinal (GI) toxicities using validated spatial and non-spatial normal-tissue complication probability (NTCP) models. Materials and methods For 26 patients DSMs of the ARW were generated. From the DSMs various shape-based dose measures were calculated at different dose levels: lateral extent, longitudinal extent, and eccentricity...
Subjects
free text keywords: Prostate cancer, Radiotherapy, Rectum spacer, Dose-surface maps, Toxicity reduction, QUALITY-OF-LIFE, POLYETHYLENE-GLYCOL HYDROGEL, MODULATED RADIATION-THERAPY, GASTROINTESTINAL TOXICITY, CONFORMAL RADIOTHERAPY, BALLOON, TRIAL, BRACHYTHERAPY, HISTOGRAMS, REDUCTION, Article, Medical physics. Medical radiology. Nuclear medicine, R895-920, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
57 references, page 1 of 4

Glass, A.S., Cowan, J.E., Fuldeore, M.J., Cooperberg, M.R., Carroll, P.R., Kenfield, S.A.. Patient demographics, quality of life, and disease features of men with newly diagnosed prostate cancer: trends in the PSA era. Urology. 2013; 82 (1): 60-65 [PubMed]

Krol, R., Smeenk, R.J., van Lin, E.N., Hopman, W.P.. Impact of late anorectal dysfunction on quality of life after pelvic radiotherapy. Int J Colorectal Dis. 2013; 28 (4): 519-526 [PubMed]

Vanneste, B.G., Van De Voorde, L., de Ridder, R.J., Van Limbergen, E.J., Lambin, P., van Lin, E.N.. Chronic radiation proctitis: tricks to prevent and treat. Int J Colorectal Dis. 2015; 30 (10): 1293-1303 [OpenAIRE] [PubMed]

Smeenk, R.J., Van Lin, E.N.J.T.. Application of anorectal sparing devices in prostate radiotherapy. Radiother Oncol. 2013; 106 (2): 155-156 [PubMed]

Pinkawa, M., Corral, N.E., Caffaro, M.. Application of a spacer gel to optimize three-dimensional conformal and intensity modulated radiotherapy for prostate cancer. Radiother Oncol. 2011; 100 (3): 436-441 [OpenAIRE] [PubMed]

Prada, P.J., Fernández, J., Martinez, A.A., de la Rúa, A., Gonzalez, J.M., Fernandez, J.M.. Transperineal injection of hyaluronic acid in anterior perirectal fat to decrease rectal toxicity from radiation delivered with intensity modulated brachytherapy or EBRT for prostate cancer patients. Int J Radiat Oncol Biol Phys. 2007; 69 (1): 95-102 [PubMed]

Melchert, C.. Interstitial biodegradable balloon for reduced rectal dose during prostate radiotherapy: results of a virtual planning investigation based on the pre- and post-implant imaging data of an international multicenter study. Radiother Oncol. 2013; 106 (2): 210-214 [OpenAIRE] [PubMed]

Noyes, W.R., Hosford, C.C., Schultz, S.E.. Human collagen injections to reduce rectal dose during radiotherapy. Int J Radiat Oncol Biol Phys. 2012; 82 (5): 1918-1922 [PubMed]

Vanneste, B.G., van De Beek, K., Lutgens, L., Lambin, P.. Implantation of a biodegradable rectum balloon implant: tips, Tricks and Pitfalls. Int Braz J Urol. 2017; 24: 43

Vanneste, B.G.L., van wijk, Y., Lutgens, L.C., Van Limbergen, E.J., van Lin, E.N., van de Beek, K.. Dynamics of rectal balloon implant shrinkage do not affect anorectal dose and late rectal complication risk in prostate VMAT. Strahlenther Onkol. 2018; 194 (1): 31-40 [OpenAIRE] [PubMed]

Song, D.Y.. A multi-institutional clinical trial of rectal dose reduction via injected polyethylene-glycol hydrogel during intensity modulated radiation therapy for prostate cancer: analysis of dosimetric outcomes. Int J Radiat Oncol Biol Phys. 2013; 87 (1): 81-87 [OpenAIRE] [PubMed]

Strom, T.J.. A dosimetric study of polyethylene glycol hydrogel in 200 prostate cancer patients treated with high-dose rate brachytherapy ± intensity modulated radiation therapy. Radiother Oncol. 2014; 111 (1): 126-131 [PubMed]

Habl, G.. Acute toxicity and quality of life in patients with prostate cancer treated with protons or carbon ions in a prospective randomized phase II study-the IPI trial. Int J Radiat Oncol Biol Phys.. 2016; 95 (1): 435-443 [OpenAIRE] [PubMed]

Fagundes, M., Han-Chih Chang, J., Michalski, J., Soffen, E., Davis, B., Pisansky, T.. In Regard to Habl et al.. Int J Radiat Oncol Biol Phys. 2016; 96 (1): 241-242 [PubMed]

Mariados, N.. hydrogel spacer prospective multicenter randomized controlled pivotal trial: dosimetric and clinical effects of perirectal spacer application in men undergoing prostate image guided intensity modulated radiation therapy. Int J Radiat Oncol Biol Phys. 2015; 92 (5): 971-977 [OpenAIRE] [PubMed]

57 references, page 1 of 4
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