publication . Article . Preprint . 2020

Coherent Fourier scatterometry reveals nerve fiber crossings in the brain

Menzel, Miriam; Pereira, Silvania F.;
Open Access English
  • Published: 14 May 2020
Abstract
Previous simulation studies by Menzel et al. [Phys. Rev. X 10, 021002 (2020)] have shown that scattering patterns of light transmitted through artificial nerve fiber constellations contain valuable information about the tissue substructure such as the individual fiber orientations in regions with crossing nerve fibers. Here, we present a method that measures these scattering patterns in monkey and human brain tissue using coherent Fourier scatterometry with normally incident light. By transmitting a non-focused laser beam (wavelength of 633 nm) through unstained histological brain sections, we measure the scattering patterns for small tissue regions (with diamet...
Subjects
free text keywords: ddc:610, Physics - Medical Physics, Physics - Biological Physics, Physics - Optics
Funded by
EC| HBP SGA2
Project
HBP SGA2
Human Brain Project Specific Grant Agreement 2
  • Funder: European Commission (EC)
  • Project Code: 785907
  • Funding stream: H2020 | SGA-RIA
,
NIH| Vervet Research Colony as a Biomedical Resource
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5P40OD010965-10
  • Funding stream: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH
,
EC| HBP SGA3
Project
HBP SGA3
Human Brain Project Specific Grant Agreement 3
  • Funder: European Commission (EC)
  • Project Code: 945539
  • Funding stream: H2020 | SGA-RIA
,
NIH| Postnatal Development of Cortical Receptors and White Matter Tracts
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5R01MH092311-03
  • Funding stream: NATIONAL INSTITUTE OF MENTAL HEALTH
Communities
FET H2020FET FLAG: HBP FET Flagship core project
FET H2020FET FLAG: Human Brain Project Specific Grant Agreement 3
FET H2020FET FLAG: HBP FET Flagship core project
FET H2020FET FLAG: Human Brain Project Specific Grant Agreement 2
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