Cerebrospinal fluid IL-12p40, CXCL13 and IL-8 as a combinatorial biomarker of active intrathecal inflammation.

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Bielekova, Bibiana; Komori, Mika; Xu, Quangang; Reich, Daniel S.; Wu, Tianxia;
(2012)
  • Publisher: Public Library of Science (PLoS)
  • Journal: PLoS ONE,volume 7,issue 11 (issn: 1932-6203, eissn: 1932-6203)
  • Publisher copyright policies & self-archiving
  • Related identifiers: doi: 10.1371/journal.pone.0048370, pmc: PMC3511462
  • Subject: Autoimmune Diseases | Demyelinating Disorders | Research Article | Biology | Diagnostic Medicine | Pathology | Multiple Sclerosis | Biomarkers | Medicine | Immunity | Q | R | Infectious Diseases of the Nervous System | Inflammation | Immune Response | Clinical Immunology | Science | Immune System | Cytokines | General Pathology | Immunology | Neurology

Diagnosis and management of the neuroinflammatory diseases of the central nervous system (CNS) are hindered by the lack of reliable biomarkers of active intrathecal inflammation. We hypothesized that measuring several putative inflammatory biomarkers simultaneously will... View more
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