Cardiac-specific inactivation of LPP3 in mice leads to myocardial dysfunction and heart failure

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Chandra, Mini; Escalante-Alcalde, Diana; Bhuiyan, Md. Shenuarin; Orr, Anthony Wayne; Kevil, Christopher; Morris, Andrew J.; Nam, Hyung; Dominic, Paari; McCarthy, Kevin J.; Miriyala, Sumitra; Panchatcharam, Manikandan;
  • Publisher: Elsevier
  • Journal: Redox Biology,volume 14,pages261-271 (eissn: 2213-2317)
  • Related identifiers: doi: 10.1016/j.redox.2017.09.015, pmc: PMC5635346
  • Subject: Lipid phosphate phosphatase | PA, phosphatidic acid | Heart failure | Lysophosphatidic acid | Plpp3, Phospholipid phosphatase 3 | LPA, lysophosphatidic acid | Research Paper

Lipid Phosphate phosphatase 3 (LPP3), encoded by the Plpp3 gene, is an enzyme that dephosphorylates the bioactive lipid mediator lysophosphatidic acid (LPA). To study the role of LPP3 in the myocardium, we generated a cardiac specific Plpp3 deficient mouse strain. Altho... View more
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