Cardiac-specific inactivation of LPP3 in mice leads to myocardial dysfunction and heart failure

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Chandra, Mini; Escalante-Alcalde, Diana; Bhuiyan, Md. Shenuarin; Orr, Anthony Wayne; Kevil, Christopher; Morris, Andrew J.; Nam, Hyung; Dominic, Paari; McCarthy, Kevin J.; Miriyala, Sumitra; Panchatcharam, Manikandan;

Lipid Phosphate phosphatase 3 (LPP3), encoded by the Plpp3 gene, is an enzyme that dephosphorylates the bioactive lipid mediator lysophosphatidic acid (LPA). To study the role of LPP3 in the myocardium, we generated a cardiac specific Plpp3 deficient mouse strain. Altho... View more
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