A Thiopurine Drug Inhibits West Nile Virus Production in Cell Culture, but Not in Mice

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Lim, Pei-Yin; Keating, Julie A.; Hoover, Spencer; Striker, Rob; Bernard, Kristen A.;
  • Publisher: Public Library of Science
  • Journal: PLoS ONE,volume 6,issue 10 (issn: 1932-6203, eissn: 1932-6203)
  • Related identifiers: doi: 10.1371/journal.pone.0026697, pmc: PMC3200352
  • Subject: Animal Models | Research Article | Biology | Yellow fever | West Nile fever | Infectious diseases | Microbiology | Medicine | Drug Research and Development | Dengue | Viral diseases | Viral Replication | Q | Mouse | R | Model Organisms | Drugs and Devices | Drug Discovery | Virology | Science
    mesheuropmc: viruses | virus diseases

Many viruses within the Flavivirus genus cause significant disease in humans; however, effective antivirals against these viruses are not currently available. We have previously shown that a thiopurine drug, 6-methylmercaptopurine riboside (6MMPr), inhibits replication ... View more