Dissociable contributions of MRI volume reductions of superior temporal and fusiform gyri to symptoms and neuropsychology in schizophrenia
Other literature type, Article
Nestor, Paul Gerard
Gurrera, Ronald Joseph
Niznikiewicz, Margaret A.
Shenton, Martha Elizabeth
McCarley, Robert William
- Publisher: Elsevier BV
symptoms | MRI | neuropsychology | schizophrenia | Article
mesheuropmc: genetic structures | behavioral disciplines and activities
We sought to identify the functional correlates of reduced magnetic resonance imaging (MRI) volumes of the superior temporal gyrus (STG) and the fusiform gyrus (FG) in patients with chronic schizophrenia. MRI volumes, positive/negative symptoms, and neuropsychological tests of facial memory and executive functioning were examined within the same subjects. The results indicated two distinct, dissociable brain structure-function relationships: (1) reduced left STG volume-positive symptoms-executive deficits; (2) reduced left FG-negative symptoms-facial memory deficits. STG and FG volume reductions may each make distinct contributions to symptoms and cognitive deficits of schizophrenia.