Gender-linked impact of epicardial adipose tissue volume in patients who underwent coronary artery bypass graft surgery or non-coronary valve surgery.

Article English OPEN
Gulinu Maimaituxun ; Michio Shimabukuro ; Hotimah Masdan Salim ; Minoru Tabata ; Daisuke Yuji ; Yoshihisa Morimoto ; Takeshi Akasaka ; Tomomi Matsuura ; Shusuke Yagi ; Daiju Fukuda ; Hirotsugu Yamada ; Takeshi Soeki ; Takaki Sugimoto ; Masashi Tanaka ; Shuichiro Takanashi ; Masataka Sata
  • Publisher: Public Library of Science (PLoS)
  • Journal: PLoS ONE, volume 12, issue 6 (issn: 1932-6203, eissn: 1932-6203)
  • Related identifiers: pmc: PMC5464529, doi: 10.1371/journal.pone.0177170
  • Subject: Adiponectin | Lipids | Vascular Medicine | Research Article | Hormones | Anatomy | Cardiovascular Procedures | Diabetes Mellitus | Endocrine Disorders | Molecular Development | Biological Tissue | Fats | Immune System | Cholesterol | Cytokines | Adipokines | Immunology | Coronary Artery Bypass Grafting | Metabolic Disorders | Blood Pressure | Surgical and Invasive Medical Procedures | Biology and Life Sciences | Immune Physiology | Developmental Biology | Physiology | Adipose Tissue | Medicine | Cardiology | Innate Immune System | Q | R | Type 2 Diabetes | Peptide Hormones | Biochemistry | Science | Coronary Heart Disease | Medicine and Health Sciences | Hypertension | Endocrinology
    mesheuropmc: surgical procedures, operative | cardiovascular diseases

Background Traditional and non-traditional risk factors for atherosclerotic cardiovascular disease (ASCVD) are different between men and women. Gender-linked impact of epicardial adipose tissue volume (EATV) in patients undergoing coronary artery bypass grafting (CABG) remains unknown. Methods Gender-linked impact of EATV, abdominal fat distribution and other traditional ASCVD risk factors were compared in 172 patients (men: 115; women: 57) who underwent CABG or non-coronary valvular surgery (non-CABG). Results In men, EATV, EATV index (EATV/body surface area) and the markers of adiposity such as body mass index, waist circumference and visceral fat area were higher in the CABG group than in the non-CABG group. Traditional ASCVD risk factors were also prevalent in the CABG group. In women, EATV and EATV index were higher in the CABG group, but other adiposity markers were comparable between CABG and non-CABG groups. Multivariate logistic regression analysis showed that in men, CABG was determined by EATV Index and other ASCVD risk factors including hypertension, dyslipidemia, adiponectin, high sensitive C-reactive protein (hsCRP) and type 2 diabetes mellitus (Corrected R2 = 0.262, p < 0.0001), while in women, type 2 diabetes mellitus is a single strong predictor for CABG, excluding EATV Index (Corrected R2 = 0.266, p = 0.005). Conclusions Our study found that multiple risk factors, including epicardial adipose tissue volume and traditional ASCVD factors are determinants for CABG in men, but type 2 diabetes mellitus was the sole determinant in women. Gender-specific disparities in risk factors of CABG prompt us to evaluate new diagnostic and treatment strategies and to seek underlying mechanisms.
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