Loss of CHD1 causes DNA repair defects and enhances prostate cancer therapeutic responsiveness

Other literature type English OPEN
Kari, Vijayalakshmi; Mansour, Wael Yassin; Raul, Sanjay Kumar; Baumgart, Simon J; Mund, Andreas; Grade, Marian; Sirma, Hüseyin; Simon, Ronald; Will, Hans; Dobbelstein, Matthias; Dikomey, Ekkehard; Johnsen, Steven A;

The CHD1 gene, encoding the chromo‐domain helicase DNA‐binding protein‐1, is one of the most frequently deleted genes in prostate cancer. Here, we examined the role of CHD1 in DNA double‐strand break (DSB) repair in prostate cancer cells. We show that CHD1 is required f... View more
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