publication . Article . 2017

Multiple species comparison of cardiac troponin T and dystrophin: unravelling the DNA behind dilated cardiomyopathy

England, Jennifer; Loughna, Siobhan; Rutland, Catrin S.;
Open Access English
  • Published: 07 Jul 2017 Journal: Journal of Cardiovascular Development and Disease, volume 4, issue 3 (issn: 2308-3425, eissn: 2308-3425, Copyright policy)
  • Publisher: MDPI
Abstract
Animals have frequently been used as models for human disorders and mutations. Following advances in genetic testing and treatment options, and the decreasing cost of these technologies in the clinic, mutations in both companion and commercial animals are now being investigated. A recent review highlighted the genes associated with both human and non-human dilated cardiomyopathy. Cardiac troponin T and dystrophin were observed to be associated with both human and turkey (troponin T) and canine (dystrophin) dilated cardiomyopathies. This review gives an overview of the work carried out in cardiac troponin T and dystrophin to date in both human and animal dilated ...
Subjects
mesheuropmc: musculoskeletal system
free text keywords: Mutation, RC666-701, Troponin, Species, Diseases of the circulatory (Cardiovascular) system, Review, Dystrophin, Dilated cardiomyopathy
150 references, page 1 of 10

1. 2. 3. 4. Wexler, R.K.; Elton, T.; Pleister, A.; Feldman, D. Cardiomyopathy: An overview. Am. Fam. Physician 2009, 79, 778-784. [PubMed]

Maron, B.J.; Towbin, J.A.; Thiene, G.; Antzelevitch, C.; Corrado, D.; Arnett, D.; Moss, A.J.; Seidman, C.E.; Young, J.B. Contemporary definitions and classification of the cardiomyopathies: An american heart association scientific statement from the council on clinical cardiology, heart failure and transplantation committee; quality of care and outcomes research and functional genomics and translational biology interdisciplinary working groups; and council on epidemiology and prevention. Circulation 2006, 113, 1807-1816.

Wieczorek, D.F.; Jagatheesan, G.; Rajan, S. The role of tropomyosin in heart disease. In Tropomyosin; Gunning, P., Ed.; Springer: New York, NY, USA, 2008; Volume 644, pp. 132-142. Kushwaha, S.S.; Fallon, J.T.; Fuster, V. Restrictive cardiomyopathy. N. Engl. J. Med. 1997, 336, 267-276. [CrossRef] [PubMed]

5. Basso, C.; Corrado, D.; Marcus, F.I.; Nava, A.; Thiene, G. Arrhythmogenic right ventricular cardiomyopathy. Lancet 2009, 373, 1289-1300. [CrossRef]

6. Towbin, J.A. Left ventricular noncompaction: A new form of heart failure. Heart Fail. Clin. 2010, 6, 453-469. [CrossRef] [PubMed]

7. Towbin, J.A.; Bowles, N.E. The failing heart. Nature 2002, 415, 227-233. [CrossRef] [PubMed]

8. Braunwald, E. Heart Disease: A Textbook of Cardiovascular Medicine, 8th ed.; Saunders: Phiadelphia, PA, USA, 2008.

9. Fatkin, D. Guidelines for the diagnosis and management of familial dilated cardiomyopathy. Heart Lung Circ. 2011, 20, 691-693. [CrossRef] [PubMed]

10. Cahill, T.J.; Ashrafian, H.; Watkins, H. Genetic cardiomyopathies causing heart failure. Circ. Res. 2013, 113, 660-675. [CrossRef] [PubMed]

11. Fleming, J.M.; Creevy, K.E.; Promislow, D.E. Mortality in north american dogs from 1984 to 2004: An investigation into age-, size-, and breed-related causes of death. J. Vet. Intern. Med. 2011, 25, 187-198. [CrossRef] [PubMed]

12. Egenvall, A.; Bonnett, B.N.; Haggstrom, J. Heart disease as a cause of death in insured Swedish dogs younger than 10 years of age. J. Vet. Intern. Med. 2006, 20, 894-903. [CrossRef] [PubMed]

13. Brownlie, S.E.; Cobb, M.A. Observations on the development of congestive heart failure in Irish wolfhounds with dilated cardiomyopathy. J. Small Anim. Pract. 1999, 40, 371-377. [CrossRef] [PubMed]

14. Simpson, S.; Edwards, J.; Ferguson-Mignan, T.F.; Cobb, M.; Mongan, N.P.; Rutland, C.S. Genetics of Human and Canine Dilated Cardiomyopathy. Int. J. Genom. 2015, 2015, 204823. [CrossRef] [PubMed]

15. Schatzberg, S.J.; Olby, N.J.; Breen, M.; Anderson, L.V.B.; Langford, C.F.; Dickens, H.F.; Wilton, S.D.; Zeiss, C.J.; Binns, M.M.; Kornegay, J.N.; et al. Molecular analysis of a spontaneous dystrophin 'knockout' dog. Neuromuscul. Disord. 1999, 9, 289-295. [CrossRef]

16. Meurs, K.M.; Lahmers, S.; Keene, B.W.; White, S.N.; Oyama, M.A.; Mauceli, E.; Lindblad-Toh, K. A splice site mutation in a gene encoding for PDK4, a mitochondrial protein, is associated with the development of dilated cardiomyopathy in the Doberman pinscher. Hum. Genet. 2012, 131, 1319-1325. [CrossRef] [PubMed]

150 references, page 1 of 10
Abstract
Animals have frequently been used as models for human disorders and mutations. Following advances in genetic testing and treatment options, and the decreasing cost of these technologies in the clinic, mutations in both companion and commercial animals are now being investigated. A recent review highlighted the genes associated with both human and non-human dilated cardiomyopathy. Cardiac troponin T and dystrophin were observed to be associated with both human and turkey (troponin T) and canine (dystrophin) dilated cardiomyopathies. This review gives an overview of the work carried out in cardiac troponin T and dystrophin to date in both human and animal dilated ...
Subjects
mesheuropmc: musculoskeletal system
free text keywords: Mutation, RC666-701, Troponin, Species, Diseases of the circulatory (Cardiovascular) system, Review, Dystrophin, Dilated cardiomyopathy
150 references, page 1 of 10

1. 2. 3. 4. Wexler, R.K.; Elton, T.; Pleister, A.; Feldman, D. Cardiomyopathy: An overview. Am. Fam. Physician 2009, 79, 778-784. [PubMed]

Maron, B.J.; Towbin, J.A.; Thiene, G.; Antzelevitch, C.; Corrado, D.; Arnett, D.; Moss, A.J.; Seidman, C.E.; Young, J.B. Contemporary definitions and classification of the cardiomyopathies: An american heart association scientific statement from the council on clinical cardiology, heart failure and transplantation committee; quality of care and outcomes research and functional genomics and translational biology interdisciplinary working groups; and council on epidemiology and prevention. Circulation 2006, 113, 1807-1816.

Wieczorek, D.F.; Jagatheesan, G.; Rajan, S. The role of tropomyosin in heart disease. In Tropomyosin; Gunning, P., Ed.; Springer: New York, NY, USA, 2008; Volume 644, pp. 132-142. Kushwaha, S.S.; Fallon, J.T.; Fuster, V. Restrictive cardiomyopathy. N. Engl. J. Med. 1997, 336, 267-276. [CrossRef] [PubMed]

5. Basso, C.; Corrado, D.; Marcus, F.I.; Nava, A.; Thiene, G. Arrhythmogenic right ventricular cardiomyopathy. Lancet 2009, 373, 1289-1300. [CrossRef]

6. Towbin, J.A. Left ventricular noncompaction: A new form of heart failure. Heart Fail. Clin. 2010, 6, 453-469. [CrossRef] [PubMed]

7. Towbin, J.A.; Bowles, N.E. The failing heart. Nature 2002, 415, 227-233. [CrossRef] [PubMed]

8. Braunwald, E. Heart Disease: A Textbook of Cardiovascular Medicine, 8th ed.; Saunders: Phiadelphia, PA, USA, 2008.

9. Fatkin, D. Guidelines for the diagnosis and management of familial dilated cardiomyopathy. Heart Lung Circ. 2011, 20, 691-693. [CrossRef] [PubMed]

10. Cahill, T.J.; Ashrafian, H.; Watkins, H. Genetic cardiomyopathies causing heart failure. Circ. Res. 2013, 113, 660-675. [CrossRef] [PubMed]

11. Fleming, J.M.; Creevy, K.E.; Promislow, D.E. Mortality in north american dogs from 1984 to 2004: An investigation into age-, size-, and breed-related causes of death. J. Vet. Intern. Med. 2011, 25, 187-198. [CrossRef] [PubMed]

12. Egenvall, A.; Bonnett, B.N.; Haggstrom, J. Heart disease as a cause of death in insured Swedish dogs younger than 10 years of age. J. Vet. Intern. Med. 2006, 20, 894-903. [CrossRef] [PubMed]

13. Brownlie, S.E.; Cobb, M.A. Observations on the development of congestive heart failure in Irish wolfhounds with dilated cardiomyopathy. J. Small Anim. Pract. 1999, 40, 371-377. [CrossRef] [PubMed]

14. Simpson, S.; Edwards, J.; Ferguson-Mignan, T.F.; Cobb, M.; Mongan, N.P.; Rutland, C.S. Genetics of Human and Canine Dilated Cardiomyopathy. Int. J. Genom. 2015, 2015, 204823. [CrossRef] [PubMed]

15. Schatzberg, S.J.; Olby, N.J.; Breen, M.; Anderson, L.V.B.; Langford, C.F.; Dickens, H.F.; Wilton, S.D.; Zeiss, C.J.; Binns, M.M.; Kornegay, J.N.; et al. Molecular analysis of a spontaneous dystrophin 'knockout' dog. Neuromuscul. Disord. 1999, 9, 289-295. [CrossRef]

16. Meurs, K.M.; Lahmers, S.; Keene, B.W.; White, S.N.; Oyama, M.A.; Mauceli, E.; Lindblad-Toh, K. A splice site mutation in a gene encoding for PDK4, a mitochondrial protein, is associated with the development of dilated cardiomyopathy in the Doberman pinscher. Hum. Genet. 2012, 131, 1319-1325. [CrossRef] [PubMed]

150 references, page 1 of 10
Powered by OpenAIRE Open Research Graph
Any information missing or wrong?Report an Issue
publication . Article . 2017

Multiple species comparison of cardiac troponin T and dystrophin: unravelling the DNA behind dilated cardiomyopathy

England, Jennifer; Loughna, Siobhan; Rutland, Catrin S.;